The 3rd Calibration and Validation Group Workshop on Recent Issues in Regulated Bioanalysis was organized by the Calibration and Validation Group as a 1.5-day full immersion workshop for contract research organizations, pharmaceutical companies and regulatory agencies to discuss several 'hot' topics concerning bioanalytical issues and regulatory challenges. A consensus was reached among panelists and attendees on many points regarding method validation of small molecules.

This event was organized by the Calibration and Validation Group (a scientific nonprofit organization based in Toronto, Canada) as a 1.5-day workshop for contract research organizations and pharmaceutical companies involved in providing bioanalytical data for bioavailability, bioequivalence, pharmacokinetic and comparability studies.

In our last issue we published Mr. Joseph Alsop's controversial thesis on the present situation within China under the above title. We have asked a number of specialists on the economics and politics of contemporary China to comment on his article. ALEXANDER ECKSTEIN MR. Alsop in his most interesting article advances four basic propositions: 1. There are limits to the hardships which any government can safely inflict upon the governed. These limits will vary from society to society depending upon a host of factors such as climate, historical conditioning, customary standard of living, etc. 2. Communist China is caught in a remorselessly descending spiral, which if not reversed will drive the system to the breaking point. 3. This breaking point seems to be near and may in fact be reached if this year's harvest also turns out to be poor. 4. The break may lead to three alternative types of development: a New Economic Policy-somewhat along the lines followed by Lenin in the early twenties-a new type of Communist regime perhaps emulating the Polish example, or a total collapse under the pressure of an elemental peasant rebellion in the tradition of Chinese rebellions of the past. Of these three alternatives, the first seems least likely, while the chances for the last would increase in proportion with a worsening food situation.

Lindsay sets forth systematic procedures for designing and conducting follow-up studies of teacher education graduates. Specifically, the author makes recom mendations with regard to formulating instrument questions and scales, deter mining the length and appearance of the questionnaire, writing the cover letter, planning the follow-up reminder proce dures, and comparing nonrespondents and respondents.

Recent scholarship in educational research has provided an increasing amount of criticism of the models and investigative methodologies presently available in the field of education. This criticism has been directed toward the models and methodologies available in curriculum

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