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It has been previously shown that Micrococcus luteus possesses a pyrimidine dimer‐specific endonuclease which in vitro, functions as both an endonuclease and DNA‐glycosylase. To determine if these combined activities function in vivo, we have isolated and examined the excision products of UV‐irradiated M. luteus. In addition, we have devised a procedure to isolate and examine the excision products from UV‐irradiated human fibroblasts to determine if an endonuclease/glycosylase activity functions in the excision of UV‐induced pyrimidine dimers in human fibroblasts. We find that, in vivo, an endonuclease/glycosylase mechanism is utilized extensively in the repair of pyrimidine dimers by M. luteus, but that human fibroblasts do not appear to use this mechanism.

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