Four antitumor drug combinations which are currently in clinical use were evaluated experimentally using the murine B 16 melanoma model. Bleomycin plus vinblastine produced an increase in life span over either of the two agents alone against both intraperitoneal and subcutaneous B16. This combination also resulted in a large number of long-term survivors. Bleomycin plus cis-platinum produced slight enhancement against subcutaneous B 16, but showed no advantage against intraperitoneal B16. The combination of 5-fluorouracil plus methyl-CCNU significantly increased survival time against the intraperitoneal tumor, and produced long-term survivors as well. The combination of 5-fluorouracil plus BCNU was not more effective than BCNU or 5-fluorouracil alone. These data were compared with the degree of success reported from the clinics against a variety of solid human neoplasms.Cancer 42: 171 1 -1719, 1978.OUR COMBINATIONS CHOSEN FOR analysis F in this report are of particular interest since they are currently being used clinically in the treatment of human solid tumors. The rationale for the conduct of clinical trials with these combinations has been that the regression rates for these drugs alone have been substantial, while their side effects were of different types and occurred at different times. The expectation was that the combinations of agents might produce increased therapeutic benefits without compounding toxicity.One combination tested was bleomycin (NSC 125066) and vinblastine (NSC 49842). Bleomycin is active as a single agent against testicular cancers,21,22 and is a good candidate for combination chemotherapy due to its lack of myel~suppression
Certain topological conditions on a Markov transition function are shown sufficient for an integral representation of conservative invariant Baire measures. The analysis incorporates the Choquet-Bishop-de Leeuw extension of the Krein-Milman theorem.
Abstract.Certain topological conditions on a Markov transition function are shown sufficient for an integral representation of conservative invariant Baire measures. The analysis incorporates the Choquet-Bishop-de Leeuw extension of the KreinMilman theorem.
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