Biological processes involving the random interaction of d species with integer particle numbers are often modeled by a Markov jump process on N d 0 . Realizations of this process can, in principle, be generated with the classical stochastic simulation algorithm proposed in [19], but for very reactive systems this method is usually inefficient. Hybrid models based on piecewise deterministic processes offer an attractive alternative which can decrease the simulation time considerably in applications where species with rather low particle numbers interact with very abundant species. We investigate the convergence of the hybrid model to the original one for a class of reaction systems with two distinct scales. Our main result is an error bound which states that, under suitable assumptions, the hybrid model approximates the marginal distribution of the discrete species and the conditional moments of the continuous species up to an error of O`M −1´w here M is the scaling parameter of the partial thermodynamic limit.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.