Abstract. Quantum fields propagating on a curved spacetime are investigated in terms of microlocal analysis. We discuss a condition on the wave front set for the corresponding n-point distributions, called "microlocal spectrum condition" (µSC). On Minkowski space, this condition is satisfied as a consequence of the usual spectrum condition. Based on Radzikowski's determination of the wave front set of the two-point function of a free scalar field, satisfying the Hadamard condition in the Kay and Wald sense, we construct in the second part of this paper all Wick polynomials including the energy-momentum tensor for this field as operator valued distributions on the manifold and prove that they satisfy our microlocal spectrum condition.

The application of a liquid/liquid microsegmented flow for serial high-throughput microanalytical systems shows promising prospects for applications in clinical chemistry, pharmaceutical research, process diagnostics, and analytical chemistry. Microscopy and microspectral analytics offer powerful approaches for the analytical readout of droplet based assays. Within the generated segments, individuality and integrity are retained during the complete diagnostic process making the approach favored for analysis of individual microscaled objects like cells and microorganisms embedded in droplets. Here we report on the online application of surface-enhanced micro-Raman spectroscopy for the detection and quantization of analytes in a liquid/liquid segmented microfluidic system. Data acquisition was performed in microsegments down to a volume of 180 nl. With this approach, we overcome the well-known problem of adhesion of colloid/analyte conjugates to the optical windows of detection cuvettes, which causes the so-called "memory effect". The combination of the segmented microfluidic system with the highly sensitive SERS technique reaches in a reproducible quantification of analytes with the SERS technique.

The conceptual structure of the aesthetics of objects was investigated. To this end, associative namings for the word "aesthetics" were collected from 311 nonartist German college students in a timed verbal association task. 590 different adjectives were produced, depicting diversification of the concept. The adjective "beautiful" was given by more than 90% of the participants. The adjective "ugly" was the second most frequent naming, used by almost half of the students. All other namings were markedly less frequently produced. It is argues that the beautiful-ugly dimension represents the primary concept in the aesthetics of objects, so that performing aesthetic judgments of the beauty of objects comes naturally to individuals. In other words, the most prototypical aesthetic judgments are those of beauty. Furthermore, the majority of generated words had a positive valence as measured by an additional valence-rating study including 41 participants. This result contrasts with comparable studies of emotion terms, as such studies typically show a negativity bias. Frequency in general language use and valence of the adjectives did not account for the results.

The protocol selected in the initial phase, now available as a WBC-reduction system, results in platelet concentrates with very low residual WBC levels. This satisfies even the most stringent criteria for WBC reduction in platelets, without the platelet loss typically seen with conventional fiber filtration.

Abstract. Renew is a computer tool that supports the development and execution of object-oriented Petri nets, which include net instances, synchronous channels, and seamless Java integration for easy modelling. Renew is available free of charge including the Java source code. Due to the growing application area more and more requirements had to be fulfilled by the tool set. Therefore, the architecture of the tool has been refactored to gain more flexibility. Now new features allow for plug-ins on the level of concepts (net formalisms) and on the level of applications (e.g. workflow or agents).

Abstract. This work proposes a way to model the structure and behaviour of agents in terms of executable coloured Petri net protocols. Structure and behaviour are not all aspects of agent based computing: agents need a world to live in (mostly divided into platforms), they need a general structure (e.g. including a standard interface for communication) and their own special behaviour. Our approach tackles all three parts in terms of Petri nets. This paper skips the topic of agent platforms and handles the agent structure briefly to introduce a key concept of our work: the graphical modelling of the behaviour of autonomous and adaptive agents. A special kind of coloured Petri nets is being used throughout the work: reference nets. Complex agent behaviour is achieved via dynamic composition of simpler sub-protocols, a task that reference nets are especially well suited for. The inherent concurrency of Petri nets is another point that makes it easy to model agents: multiple threads of control are (nearly) automatically implied in Petri nets.

HighlightsContent-based search avoids information overload in IHE XDS Shared EHR systems.Content-based search enables retrieval of fine-grained information items.Content-based search implemented by integrating Archetypes in IHE XDS.

Purpose: To evaluate factors associated with survival following transarterial 90Y (yttrium) radioembolization (TARE) in patients with advanced intrahepatic cholangiocarcinoma (ICC). Methods: This retrospective multicenter study analyzed the outcome of three tertiary care cancer centers in patients with advanced ICC following resin microsphere TARE. Patients were included either after failed previous anticancer therapy, including relapse after surgical resection, or for having a minimum of 25% of total liver volume affected by ICC. Patients were stratified and response was assessed by the Response Evaluation Criteria in Solid Tumors (RECIST) criteria at 3 months. Kaplan–Meier analysis was performed to analyze survival followed by cox regression to determine independent prognostic factors for survival. Results: 46 patients were included (19 male, 27 female), median age 62.5 years (range 29–88 years). A total of 65% of patients had undergone previous therapy, while 63% had a tumor volume > 25% of the entire liver volume. Median survival was 9.5 months (95% CI: 6.1–12.9 months). Due to loss in follow-up, n = 37 patients were included in the survival analysis. Cox regression revealed the extent of liver disease to one or both liver lobes being associated with survival, irrespective of tumor volume (p = 0.041). Patients with previous surgical resection of ICC had significantly decreased survival (3.9 vs. 12.8 months, p = 0.002). No case of radiation-induced liver disease was observed. Discussion: Survival after 90Y TARE in patients with advanced ICC primarily depends on disease extent. Only limited prognostic factors are associated with a general poor overall survival.