Data was collected in the field, from an office building located in Frankfurt, Germany, over the period of 4 years. The building was designed as a low-energy building and featured natural ventilation for individual control of air quality as well as buoyancy-driven night ventilation in combination with a central atrium as a passive cooling strategy. The monitored data include in total 116 data points related to outdoor and indoor environmental data, energy related data, and data related to occupancy and occupant behaviour. Data points representing a state were logged with the real timestamp of the event taking place, all other data points were recorded in 10 minute intervals. Data were collected in 17 cell offices with a size of ~20 m2, facing either east or west). Each office has one fixed and two operable windows, internal top light windows between office and corridor (to allow for night ventilation into the atrium) and sun protection elements (operated both manually and automatically). Each office is occupied by one or two persons.
AIMS OF THE STUDY:To investigate and compare the centre-specific short-term outcome indicators seizures, arterial hypotension, infection and mortality during therapeutic hypothermia until discharge from the neonatal/paediatric intensive care unit in term and near-term neonates with hypoxic-ischaemic encephalopathy (HIE) registered in the Swiss National Asphyxia and Cooling Register between 2011 and 2018.METHODS: Retrospective analysis of prospectively collected national register data between 1 January 2011 and 31 December 2018. Pregnancy, maternal, delivery and neonatal characteristics were compared between the centres. Four short-term outcomes were defined: seizures, arterial hypotension, infection and mortality. The outcome indicators were defined as stated in the protocol of the Swiss National Asphyxia and Cooling Register. Descriptive analyses of the de-identified centre to centre analysis were performed, and standardised observed-to-expected values (risk adjusted for male sex, small for gestational age, Sarnat score on admission, pregnancy/delivery complications) of each centre were compared using with the entire network indirectly standardised mortality/morbidity ratio charts. RESULTS: 570 cooled neonates with HIE receiving therapeutic hypothermia in 10 different centres were included. Clinical or subclinical seizures were reported in a median of 32% (range 17-49%). Arterial hypotension occurred in a median of 62% (range 30-90%). Median infection rate was 10% (range 0-31%). Median mortality rate until discharge was 14% (range 0-25%).CONCLUSIONS: Short-term outcome indicators of seizures, arterial hypotension, infection and mortality showed significant differences in incidence between the centres. These data will help to establish benchmarks for the assessed outcome measures. Benchmarking is a con-tinuous need with the ultimate goal of improving modifiable short-term outcomes in neonates with HIE.
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