This is the first study to document the clinical impact of frequent molecular monitoring, and the findings underscore the importance of regular molecular monitoring in delivering quality care for CML. These findings could be subject to unobserved confounders.
Treatment failure is frequent among IBS-C and CC patients, and sub-optimal treatment response with available IBS-C and CC therapies may lead to substantial HRU and healthcare costs.
Only short-term effects of disease activity change were investigated, disregarding other potential benefits of low disease activity on long-term organ damage prevention or comorbidities.
Objective Hidradenitis suppurativa (HS) is often treated by surgery. The risk of recurrence after surgery is common and the consequences are substantial, but neither has been quantified using a claims database. This study aimed to estimate the burden associated with non-curative surgery in HS patients. Methods A retrospective analysis was performed of health insurance claims data from Q1 1999 to Q2 2011 in a US claims database. The analysis included 2668 adults with ≥1 diagnosis of HS and ≥1 claim for skin surgery within 6 months after diagnosis. Healthcare resource utilization and medical costs were compared using multivariate regressions. Results Overall, 46% of HS patients had ≥1 indicator of non-curative surgery. The incidences of inpatient, emergency department, and outpatient visits were 88%, 40%, and 30% higher, respectively, for patients with non-curative surgery vs patients without indicator of non-curative surgery (all p < 0.001). Average medical costs were $11,858 and $6427 for patients with and without indicators of non-curative surgery, respectively. The difference of $4185 (p < 0.001) was mainly driven by inpatient costs (difference = $2685; p < 0.001). Limitations Indicators of non-curative HS surgery were defined based on an empirical algorithm. Conclusions Non-curative HS surgery occurred in almost half of all cases and represents a significant burden on patients and payers in terms of resource utilization and costs.
SUMMARYThe objective of this study was to determine sTNF-R, type I (p55) and type II (p75) in sera of HlVinfeeted male homosexuals and correlate them to T lymphocyte subpopulations and course of HIV infeetion. Scrum samples were obtained from 39 HIV-I "^ asymptomatie male homosexuali, 10 symptomatic (ARC and AIDS) male hotiiosexuals and 44 HIV non-homosexual healthy conirols. sTNF-R levels were determined by ELISA with specific MoAbs and polyclonal antibodies to the sTNE"-R proteins. sTNF-Rl and II levels were significantly elevated in 72' yr> and 74'^ respectively of HIV asymptomatic male homosexuals and in all of the symptomatic male homosexuals. In sequential studies a highly significant positive correlation was found between sTNF-RI and sTNF-RJI (r = 0-8, /•< 0-001) and between both sTNE-R jjnd CDH^ lymphocyte eotjnts (/• = 0'6 and 0-92. respectively, /'
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