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Although the primary end point of this study (that is, improvement in terms of shoulder pain at thirteen weeks) was not achieved, the overall findings, including secondary end points, indicate that sodium hyaluronate (500 to 730 kDa) is effective and well tolerated for the treatment of osteoarthritis and persistent shoulder pain that is refractory to other standard nonoperative interventions.

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Conservative treatment of acute anterior cruciate ligament injuries was recommended to selected patients, including those with sedentary occupations, low athletic demands, or ages greater than 30 years. Patients with generalized hyperligamentous laxity were excluded. Fifty-five of 61 patients were available at an average followup of 46 months from the time of initial injury. At followup, giving-way symptoms had not occurred in 23 patients (42%); in 22 (40%) giving way occurred occasionally. Of the 44 patients involved in high- or moderate-demand athletics, 33 (70%) were able to continue with moderate-demand sports. Presence of a medial collateral ligament sprain did not affect the longterm function. Forty-eight percent of the patients scored excellent or good (9 and 18 patients, respectively) on the Hospital for Special Surgery ligament scoring system; 8 (15%) later chose surgical reconstruction. The remaining 47 patients did not believe that their symptoms were severe enough to warrant any further intervention. In a group of individuals who are older and relatively inactive, nonoperative management of anterior cruciate ligament injuries can yield satisfactory results, provided the patients are willing to accept a modest amount of instability and a slight risk of meniscal injury.

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