Antifreeze glycoproteins (AFGPs) are polymeric natural products that have drawn considerable interest in diverse research fields owing to their potent ice recrystallization inhibition (IRI) activity. Self-assembled materials have emerged as a promising class of biomimetic ice growth inhibitor, yet the development of AFGP-based supramolecular materials that emulate the aggregative behavior of AFGPs have not yet been reported. This work reports the first example of the 1D self-assembly and IRI activity of AFGP-functionalized perylene bisimides (AFGP-PBIs). Glycopeptide-functionalized PBIs underwent 1D self-assembly in water and showed modest IRI activity, which could be tuned through substitution of the PBI core. This work presents essential proof-of-principle for the development of novel IRIs as potential supramolecular cryoprotectants and glycoprotein mimics.
A trimellitic imide ligand (GlyTMI2-), derived from glycine, has been used in the formation of three coordination polymers as a means towards understanding the role of the aromatic core of the ligand in determining structure. The polymeric structures poly-{(N(CH3)2H2)[Zn2(GlyTMI)2(OAc)(DMF)0.5(CH3OH)0.5]·CH3OH} (1), poly-[Cd2(GlyTMI)2(DMF)3] (2), and poly-{[Cd2(GlyTMI)2(4,4’-bipy)2]·2H2O·DMF} (3) have different dimensionalities, attributed to the change in size of the metal ion (Zn vs. Cd).
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