The reversible switching
of catalytic systems capable of performing
complex DNA computing operations using the temporal control
of two orthogonal photoswitches is described. Two distinct photoresponsive
molecules have been separately incorporated into a split horseradish
peroxidase-mimicking DNAzyme. We show that its catalytic function
can be turned on and off reversibly upon irradiation with specific
wavelengths of light. The system responds orthogonally to a
selection of irradiation wavelengths and
durations of irradiation. Furthermore, the DNAzyme exhibits reversible
switching and retains this ability throughout multiple switching cycles.
We apply our system as a light-controlled 4:2 multiplexer. Orthogonally
photoswitchable DNAzyme-based catalysts as introduced here have potential
use for controlling complex logical operations and for future applications
in DNA nanodevices.
Graphene nanoribbons (GNRs) would be the ideal building blocks for all carbon electronics; however, many challenges remain in developing an appropriate nanolithography that generates high-quality ribbons in registry with other devices. Here we report direct and local fabrication of GNRs by thermochemical nanolithography, which uses a heated AFM probe to locally convert highly insulating graphene fluoride to conductive graphene. Chemically isolated GNRs as narrow as 40 nm show p-doping behavior and sheet resistances as low as 22.9 KΩ/□ in air, only approximately 10× higher than that of pristine graphene. The impact of probe temperature and speed are examined as well as the variable-temperature transport properties of the GNR.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.