By conferring allele-specific transcriptional activity on the monoamine oxidase A (MAOA) gene in humans, length variation of a repetitive sequence [(variable number of tandem repeat (VNTR)] in the MAOA promoter influences a constellation of personality traits related to aggressive and antisocial behavior and increases the risk of neurodevelopmental and psychiatric disorders. Here, we have analyzed the presence and variability of this MAOA promoter repeat in several species of nonhuman primates. Sequence analysis of MAOA's transcriptional control region revealed the presence of the VNTR in chimpanzee (Pan troglodytes), bonobo (Pan paniscus), gorilla (Gorilla gorilla), orangutan (Pongo pygmaeus), rhesus macaque (Macaca mulatta) and Gelada baboon (Theropithecus gelada). The majority of P. troglodytes and P. paniscus showed a single repeat with a sequence identical to the VNTR sequence in humans. In contrast, analyses of the remaining species revealed shorter sequences similar to the first 18 bp of human VNTR. Compared with other nonhuman primates, the VNTR sequence of M. mulatta showed the highest length variability with allele frequencies of 35, 25 and 40% for the five, six and seven repeat variants, respectively. The extent of variability of the MAOA promoter repeat in both rhesus monkeys and humans supports the notion that there may be a relationship between functional MAOA expression and aggression-related traits in humans and rhesus macaque populations.

The article investigates the relevance of the concepts of truth and truthfulness in culturalistic, psychoanalytical and neuro-biological theories of trauma from a philosophical point of view. The background for this is the recent claim of some brain scientists to produce an overall view of the human situation. This claim is shown to be false. The article comes to the conclusion that the subjective perception of a traumatic event is indispensable in order to understand the phenomena of post-traumatic stress disorder (PTSD). History and other moral sciences are always concerned with the reconstruction of past internal perspectives. The example of trauma shows that this work is indispensable wherever brain research might lead us to.

Die philosophischen Voraussetzungen und Folgen bildgebender Verfahren in den Wissenschaften werden betrachtet. Rechnen und Abbilden, Verfahren, die ehemals in Konflikt zueinander gesehen wurden, sind heute ineinander überführbar. Es sieht so aus, als würden auch in Zukunft Bilder immer wichtiger in der Wissenschaft. Das sollte jedoch nicht zu neuen Illusionen führen, dass vermeintlich unmittelbare Einsichten in das Wesen der Dinge möglich seien.

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