Trisaccharide 23 and sulfated disaccharide 28 have been prepared by a strategy whereby the glucuronic acid moieties were introduced at a late stage of a synthetic sequence by selective oxidation of primary hydroxy groups with TEMPO and NaOCl. During the oxidation step, the primary hydroxy groups of glucosamine moieties were efficiently protected as TBDPS ethers. The oxidation procedure and removal of the TBDPS groups proved to be compatible with the presence of sulfate esters.
In volunteers, clinically relevant fluid volumes can be rapidly delivered subcutaneously with rHuPH20 in a well-tolerated manner without a pump. These findings suggest that this method of hydration could potentially replace intravenous infusions in many clinical settings; further studies with rHuPH20, in patients, are warranted.
Intravesical administration of poly(methylidene malonate 2.1.2) paclitaxel microspheres is a promising approach for intracavitary chemotherapy of superficial bladder cancer.
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