SummaryThis study aimed to determine the outcome of patients with relapsed or refractory lymphoma who have an inadequate response to first‐line salvage therapy (1°ST) and who subsequently receive a second‐line salvage regimen (2°ST) with the intention of ultimately proceeding to high‐dose therapy. The outcome of 57 patients [Hodgkin's Lymphoma 17, histologically‐aggressive non‐Hodgkin's Lymphoma (NHL) 26, histologically‐indolent NHL 14] who received more than one modality of conventional‐dose salvage therapy was analysed. Sixteen patients had a partial response (PR) to 1°ST, but subsequently received 2°ST because the PR was judged to be inadequate (iPR) because of persisting disease bulk or marrow infiltration. Of these 16 patients, 10 (63%) continued to respond to 2°ST. Of the 15 patients who had stable disease following 1°ST, 5 (33%) responded to 2°ST. Only one of the 24 (4%) with progressive disease (PD) following 1°ST, responded to 2°ST. 25 of the 57 patients ultimately underwent stem cell transplantation. The 2‐year progression‐free survival (PFS) and the 3‐year overall survival (OS) for all patients was 24% and 31%, respectively. Long‐term survival was highly dependent on response to 1°ST (P = 0·0001); in patients with PD following 1°ST, the PFS and OS at 3 years was only 4%. This analysis indicates that patients with malignant lymphomas, who have PD on 1°ST, are not rescued by subsequent salvage regimens. They should either be treated palliatively or novel approaches should be explored.
By considering multiple perspectives on the problem of networking and networks in public policy circles, as well as the wider professional world, this article aims to both draw out and blur boundaries and definitions among multiple levels of networking as an analytic concept, a fieldwork method and a practice observed among policymakers. In making this distinction and explaining it in relation to theorisations of fieldwork rapport and 'complicity,' the article attempts to show that the distance and collegiality that defines professional networking is a viable and potentially quite insightful mode, means and method for conducting fieldwork, particularly for multisited anthropology of public policy projects. To that end, this article offers both conceptual ideas, as well as practical advice for conceiving and conducting fieldwork for an anthropology of public policy project.
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