No abstract

To determine whether and to what extent one component of the extracellular matrix, fibrillar collagen, contributes causally to abnormalities in viscoelasticity, collagen was acutely degraded by activation of endogenous matrix metalloproteinases (MMPs) with the serine protease plasmin. Papillary muscles were isolated from normal cats and cats with right ventricular pressure overload hypertrophy (POH) induced by pulmonary artery banding. Plasmin treatment caused MMP activation, collagen degradation, decreased the elastic stiffness constant, and decreased the viscosity constant in both normal and POH muscles. Thus, whereas many mechanisms may contribute to the abnormalities in myocardial viscoelasticity in the POH myocardium, changes in fibrillar collagen appear to play a predominant role.

‘Prestige’ poinsettias (Euphorbia pulcherrima Willd. Ex Klotzsch) were grown at different fertilizer rates in three pine tree substrates (PTS) made from loblolly pine trees (Pinus taeda L.) and a peat-based control. Pine tree substrates were produced from pine trees that were chipped and hammer-milled to a desired particle size. Substrates used in this study included peat-lite (PL), PTS produced with a 2.38-mm screen (PTS1), PTS produced with a 4.76-mm screen (PTS2), and PTS produced with a 4.76-mm screen and amended with 25% peatmoss (v/v) (PTS3). Initial and final substrate physical properties and substrate shrinkage were determined to evaluate changes over the production period. Poinsettias were grown in 1.7-L containers in the fall of 2007 and fertilized at each irrigation with 100, 200, 300, or 400 mg·L−1 nitrogen (N). Shoot dry weight and growth index were higher in PL at 100 mg·L−1 N but similar for all substrates at 300 mg·L−1 N. Bract length was generally the same or longer in all PTS-grown plants compared with plants grown in PL at each fertilizer rate. Postproduction time to wilting was the same for poinsettias grown in PL, PTS1, and PTS3. Initial and final air space was higher in all PTSs compared with PL and container capacity (CC) of PTS1 was equal to PL initially and at the end of the experiment. The initial and final CC of PTS2 was lower than PL. The incorporation of 25% peat (PTS3) increased shoot dry weight and bract length at lower fertilizer rates compared with 4.76 mm PTS alone (PTS2). Substrate shrinkage was not different between PL and PTS1 but greater than shrinkage with the coarser PTS2. This study demonstrates that poinsettia can be successfully grown in a PTS with small particles (2.38-mm screen) or a PTS with large particles (4.76-mm screen) when amended with 25% peatmoss, which results in physical properties (CC and air space) similar to those of PL.

This article evaluates abuse-deterrent formulations (ADFs) as a method to reduce prescription drug abuse while ensuring access to vital medications for individuals with legitimate need; assesses the pros and cons of ADFs and the current state of ADF adoption in the market; and develops policy recommendations to transition the market to ADFs. Although abuse-deterrent technology is still in its nascent stages, ADFs have been proven to reduce prescription drug abuse and its consequences, and even an incremental reduction in abuse can have a significant impact on the nation by reducing the costly social, physical, mental, and public health problems resulting from abuse. Federal ADF policy does not reflect the urgency of the prescription drug abuse epidemic and does not go far enough toward changing the status quo. Policies must be implemented to encourage innovation and a market shift toward ADFs by ensuring any generic medication that references a branded ADF demonstrates that it does not have abuse-deterrent properties inferior to the branded ADF product. Policies must also require federal prescription drug benefit plans to cover ADFs to ensure consumers have access to such medications.