20 consecutive prematures with hyaline membrane disease (BMD) were randomized into 10 controls (CG) and 10 treated patientstG) at 7 days of age if they still required ventilator assistance or I oxygen (F10 < 0.21). The TG received a single bolus IV dose of furosemide PF) lmgm/k/day for 4 days and the CG received no diuretic. Mean gestational age of TG was 29 weeks (range 26-31) and of CG was DO weeks(range 27-36). Birth weight of TG was 1024 gm (range 740-1200) and of CG was 1260gm(rarrge 840-2360). All 20 infants had arterial blood gases and lung compliance (CL) measured at 2 hours, diuresis, natriuresis, F excretion and serum F levels monitored for 6 hours. At 2 hours after F dose, the TG demonstrated improved lung compliance(p <.01). This improvement was not sustained over the 72 hour study period. The mean A-a DO2 in the TG tended to decrease over 2 hours after the F dose(p=0.05) with improvement at 72 hours. Mean urine volume during 6 hours in TG was 33.9521 ml and in CG was 25.35 13 ml(p=.35NS). 6 hour sodium excretion was 1.76 mEq(TG) anf 1.45 mEq(CG). There was no correlaLion between 2 hour serum F levels and 2 hour percent CLchange Urine was collected between time 0-2 hours after F dose. On day 4, the 2 hour CL change correlated with this 2 hour urine volume(r=0.82, pd.05) the 2 hour urinary sodium(r=0.94,< 0.05) and the 2 hour urine F(p=0.07). Despite poor renal clearance of P the pulmonary effects are related to its diuretic effect. The lack of sustained pulmonary effect is explained by the brief diuresis.
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