This pharmacologic strategy permits the selective and rapid delivery of extremely high doses of DDP to head and neck carcinomas with minimal procedural complications, low systemic toxicity, and high tumor response rates.
Sodium thiosulfate kinetics were studied in eight subjects, six of whom were given the drug as a cisplatin neutralizer. Thiosulfate at a dose of 12 gm/m2 was injected by continuous intravenous infusion over 6 hr. Under these conditions, steady-state plasma concentrations were not achieved and apparent volume of distribution could not be calculated. The drug was eliminated from plasma by first-order kinetics, and the data best fit a one-compartment kinetic model with a t1/2 (mean +/- SD) of 80 +/- 38 min. Total body thiosulfate clearance was 190 +/- 76 ml/min/m2 and renal clearance was 50 +/- 11 ml/min/m2. The plasma elimination t1/2 and renal thiosulfate clearance correlated poorly with clearance of endogenous creatinine. Only 28.5% +/- 9.4% of the thiosulfate was recovered unchanged in the urine. Urinary excretion was rapid, with approximately 95% of recoverable drug eliminated within 4 hr after termination of the infusion. No toxic effects of thiosulfate were observed. These data provide the basis for the rational development of dose schedules when sodium thiosulfate is used as a cisplatin neutralizer.
A preregistered replication was conducted to examine the evidence for the basic dilution effect in a performance prediction context. Participants (n = 796) were presented with either diagnostic information alone or diagnostic + nondiagnostic information in a grade point average (GPA) prediction task. The diagnostic information was either indicative of a low GPA or a high GPA. The basic dilution effect predicts less extreme predictions when nondiagnostic information (e.g., the student describes himself as a cheerful person) is included with the diagnostic information.Despite an unusually large sample, a strong manipulation, and the use of stimulus sampling, results showed no evidence for dilution in GPA predictions. Reasons for the failure to replicate under optimal conditions are discussed.
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