Purpose: To examine and compare the levels of several metal ions released in the saliva of patients with orthodontic appliances, at different time points before and after insertion of a miniscrew. Methods: Saliva of patients (n=20) was collected at four time points: before miniscrew placement (T1), 10 minutes (T2), 7 days (T3) and 30 days after miniscrew placement (T4). The salivary samples were analyzed by inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma optical emission spectrometry (ICP-OES). The release of nine different metal ions was observed: titanium (Ti), zinc (Zn), chromium (Cr), nickel (Ni), iron (Fe), copper (Cu), aluminum (Al), Vanadium (V) and cobalt (Co). Data were analyzed by descriptive statistics. Salivary metal concentrations from different time points of miniscrew treatment were compared using Wilcoxon paired tests (α=5%). Results: At time point T4, there was a quantitative increase in the salivary concentration of Cu, Ti, V, Zn, as well as a quantitative decrease in the salivary concentration of Al, Co, Cr, Fe, Ni, when compared with T1. Conclusion: It can be concluded that the placement of fixed orthodontic appliances associated with miniscrews does not lead to an increase of salivary metal ion concentrations.
O objetivo deste estudo foi determinar a citotoxicidade induzida por mini-implantes ortodônticos conforme recebidos pelo fabricante, após a exposição a fluoretos, e após a exposição ao meio bucal. Oitenta e quatro mini-implantes de fabricantes brasileiros (SIN, INP e Neodent) foram divididos em sete grupos (n = 12): G1 - SIN como recebido do fabricante; G2 - SIN imerso durante quinze dias em NaF 0,05%; G3 - SIN exposto ao meiobucal; G4 - INP como recebido do fabricante; G5 - INP imerso durante quinze dias em NaF 0,05%; G6 - Neodent como recebido do fabricante; G7 - Neodent imerso por quinze dias em NaF 0,05%. Sua citotoxicidade foi avaliada por testes de exposição direta e indireta usando a levedura S. cerevisiae. O estresse oxidativo também foi avaliada por meio de teste de coloração de colônias. Os resultados mostraram não haver redução significativa da viabilidade celular sobre a exposição direta ou indireta a mini-implantes.
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