ABSTRACT:Porphine is the parent compound of a family of biologically and chemically relevant compounds called porphyrins. The potential of these compounds is enormous and it would be advantageous to use the porphine (porphyrin) unit as a building block for the synthesis of diverse porphyrin complexes with a wide range of applications. However, despite first being synthesised over seventy years ago, porphine has not been utilized to its full extent due to low yield syntheses and poor solubility. Recent advances have now overcome many of these problems. The purpose of this review is to illustrate the advances made in porphine chemistry to illustrate the inherent potential of this simple compound.
KEYWORDS:Porphine, porphyrin, metalloporphyrin, tetrapyrroles.
Rational building strategies and appropriate synthons have been developed for the use of triptycene as a rigid presenting scaffold. Palladium catalyzed cross-coupling reactions such as, Sonogashira and Suzuki couplings were used to install a variety of different synthetic handles around the triptycene periphery in a high yielding and controlled manner. These triptycene molecular handles were investigated for their potential in the construction of molecular arrays with defined spatial orientation e.g., for host-guest interactions or drug delivery systems. Such molecular synthons afforded expansion from the triptycene core employing arm extension increasing the internal free volume characteristic of triptycene scaffolds for such applications. In addition a range of mesogenic and glycosyl triptycene derivatives were achieved as a synthetic proof of concept for future work on potential drug delivery systems.
This article discusses the importance of recognizing pinkwashing, the practice of using the color pink and pink ribbons to indicate a company has joined the search for a breast cancer cure and to invoke breast cancer solidarity, even when the company may be using chemicals linked to cancer. This article argues that pinkwashing is a form of social injustice directed at women in the United States because the practice a) provides a vehicle for corporations to control the public experience of breast cancer, while simultaneously increasing profits and potentially contributing to the rising rate of the disease; b) obscures an environmental health discourse that recognizes the environmental causes of breast cancer; and c) co-opts or redirects women's experiences of the disease by narrowly defining what is possible.
We report the synthesis and characterization of meso-anthracenylporphyrins with zinc and nickel metal centers. A variety of novel aryl and alkyl meso-substituted anthracenylporphyrins were synthesized via step-wise Suzuki cross-coupling reactions using anthracenyl boronates. This method was compared to standard syntheses based on condensation reactions to yield anthracenylporphyrins of the A 2 B 2 -and A 3 B-type. The work was complemented by the synthesis of a number of the functionalized anthracene derivatives via Suzuki couplings. Selected systems were subjected to single-crystal X-ray analysis which revealed an unusual close packing for nickel(II) anthracenylporphyrins.
The title compound, [Ni(C60H52N4)], is an example of a meso tetrasubstituted nickel(II) porphyrin with both meso aryl and alkyl residues. The molecule exhibits a planar macrocycle with an average deviation of the 24 macrocycle atoms from their least-squares plane (Δ24) of 0.01 Å and an average Ni—N bond length of 1.960 (2) Å. The NiII atom lies on a center of inversion. The structure presents a rare example for a planar nickel(II) porphyrin, as meso-substituted nickel(II) porphyrins with either only meso-aryl or with meso-alkyl residues typically exhibit a ruffled conformation.
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