The purpose of this study was to provide clinicians in the Arab World with a child and adolescent depression screening tool. Child and parent versions of the Mood and Feelings Questionnaire (CMFQ and PMFQ respectively) were translated to Arabic and administered along with the Strengths and Difficulties Questionnaire (SDQ) to 30 children and adolescents and with mood disorders and 76 children and adolescents with other psychiatric disorders seeking treatment at a child and adolescent psychiatry clinic. DSM-IV diagnoses were generated through clinical interviews by a psychiatrist blinded to self-reports. Internal consistency for both versions was excellent with moderate inter-informant agreement and good convergent validity with the SDQ emotional symptoms subscales on the child and parent forms. The CMFQ and PMFQ significantly differentiated between currently depressed participants and those with other psychiatric disorders. CMFQ scores were a stronger predictor of categorization into depressed and non-depressed groups than the PMFQ. Two modes of cutoffs were calculated with one favoring sensitivity (a score of 26 for the CMFQ and 22 for the PMFQ) and another favoring specificity (a score of 31 for the CMFQ and 28 for the PMFQ).
The burden of genetic disorders associated with physical disabilities and psychiatric disorders is connected to increasing healthcare expenses and demands on the patients and their caregivers. Psychiatric comorbidities such as anxiety and mood disorders affect a large number of children and adolescents with genetic disorders, leading to poor quality of life and impaired psychological adjustment. Research on this population is scarce compared with studies on the comorbidity of psychiatric problems with physical illnesses (e.g., endocrine disorders and neurological problems). The aim of this review is to focus on the most prevalent genetic disorders that cause physical disability and are most commonly associated with psychiatric disorders in children and adolescents. These include Duchenne muscular dystrophy, neurofibromatosis, myotonic dystrophy, hemophilia, Turner syndrome, Klinefelter’s syndrome, tuberous sclerosis complex, fragile X syndrome and velo-cardio-facial syndrome.
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