Evidence is accumulating that chronic inflammation may have an important role in prostate cancer (PCa). Three common polymorphisms in the promoter of interleukin-10 (IL-10) gene, À1082 A4G, À819 C4T and À592 C4A, have been implicated to alter the risk of PCa, but the results of relative studies are inconclusive or controversial. To derive a more precise estimation of the relationship, we performed an updated meta-analysis on the basis of 10 studies. A comprehensive search was conducted to examine all the eligible studies of IL-10 polymorphism and PCa risk. We used odds ratios (ORs) to assess the strength of the association, and 95% confidence intervals (CIs) give a sense of the precision of the estimate. Overall, there were no significant associations between increased risk of PCa and IL-10 À1082 A4G, À819 C4T and À592 C4A polymorphisms. However, meta-analysis suggested that IL-10 À819 C4T and À592 C4A polymorphisms might be modestly associated with PCa aggressiveness (T versus C, OR ¼ 1.162, 95% CI: 1.035-1.305, P ¼ 0.011; A versus C, OR ¼ 1.131, 95% CI: 1.012-1.264, P ¼ 0.030; respectively). IL-10 À819 C4T and À592 C4A polymorphisms might impact PCa progression. Variant alleles at both À819 and À592 were modestly associated with advanced stages of PCa. Additional well-designed studies are warranted to validate these findings.
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