A simple and straightforward methodology toward the synthesis of novel 4,5-biphenyl-2-pyrimidinylguanidine compounds has been developed by one-pot reaction of biguaninde or dimethyldiguanide with isoflavones. A series of 20 new compounds was reported. All of them were characterized by FT-IR, NMR, and elemental analysis. A typical compound was determined by X-ray diffraction. A variety of substrates can participate in the process with good yields and high purities, making this methodology suitable for library synthesis in drug discovery.
A simple and straightforward methodology towards the synthesis of 2,4,5-trisubstituted pyrimidines has been developed by one-step reaction of isoflavones with thiourea or guanidine. Ten 2-mercapto-4,5-diphenylpyrimidines and eight 2-amino-4,5-diphenylpyrimidines were reported. All of them were characterized by FT-IR, NMR, and elemental analysis. A variety of substrates can participate in the process with good yields and high purities, making this methodology suitable for library synthesis in drug discovery.
One-Step Synthesis of 2,4,5-Trisubstituted Pyrimidines. -A simple and efficient method for the synthesis of the title compounds (III) and (V) is developed. The reaction of isoflavones bearing one or two hydroxy groups gives lower yields, cf. reaction of the compounds (Ic) and (Id). The reaction of the trihydroxy isoflavone genistein with the compound (II) or (IV) fails.
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.