Discussion Our study showed that essential oil extracted from ZCN obtained from Jeju Island can be safely applied to the skin and may be useful as a potential skin-whitening ingredient in cosmeceuticals to prevent re-pigmentation or post-inflammatory hyperpigmentation after laser treatment.
Magnolia grandiflora L. (Magnoliaceae) is used in traditional Chinese medicine for the treatment of colds, headaches, and stomachache [1]. The plant has also been used for the treatment of fever, diarrhea, rheumatism and arthritis [2]. Various class of compounds such as sesquiterpenoids [3][4][5], coumarins [4], phenylpropanoids [6], lignans [7], glycosides [7, 8], alkaloids [9], and other compounds [10] have been reported from this plant. The present study describes the isolation and structure determination of seven compounds 1-7 from the wood of M. grandiflora.Shade air-dried and powdered wood of M. grandiflora (22.0 kg) was extracted with 95% ethanol. The EtOH extract was concentrated under vacuum until EtOH was completely removed. The dried EtOH extract (170.17 g) was dissolved in distilled water and successively partitioned with n-hexane, dichloromethane, ethyl acetate, and n-butanol saturated with water.
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