Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV2) disease (COVID-19) is a novel threat that hampers life expectancy especially in obese individuals. Though this association is clinically relevant, the underlying mechanisms are not fully elucidated. SARS CoV2 enters host cells via the Angiotensin Converting Enzyme 2 receptor, that is also expressed in adipose tissue. Moreover, adipose tissue is also a source of many proinflammatory mediators and adipokines that might enhance the characteristic COVID-19 cytokine storm due to a chronic low-grade inflammatory preconditioning. Further obesity-dependent thoracic mechanical constraints may also incise negatively into the prognosis of obese subjects with COVID-19. This review summarizes the current body of knowledge on the obesity-dependent circumstances triggering an increased risk for COVID-19 severity, and their clinical relevance.
As of October 2020, the Severe Acute Respiratory Syndrome coronavirus 2 (SARS‐CoV‐2), responsible for Coronavirus Disease 2019 (COVID‐19), has infected over 33million individuals and killed over one million people worldwide. (
https://coronavirus.jhu.edu/map.html
accessed October 1 2020) Obesity and its complications are linked to severe forms of COVID‐19, favouring an increased hospitalization and mortality rate. Despite being the gold‐standard for the treatment of selected individuals with severe obesity, there is scarce information on whether or not bariatric surgery modifies the prognosis of people living with obesity in the current COVID‐19 pandemic. Bel Lassen and colleagues have carried out the first study with a high number of patients in their sample, bringing light into this area of uncertainty. The authors provide evidence of the importance of diabetes itself as a risk factor for severe COVID‐19.
El síndrome de apneas-hipopneas del sueño (SAHS) es una entidad muy frecuente en las sociedades desarrolladas, asociado a factores como obesidad, sexo masculino, edad, alteraciones endocrinometabólicas, anormalidades craneofaciales e historia familiar previa. Aunque las consecuencias del SAHS son todavía motivo de controversia, parece asociarse a diversas complicaciones neurocognitivas y cardiovasculares derivadas de la fragmentación del sueño y de la hipoxemia e hipercapnia durante los episodios de apnea-hipopnea. De hecho, son la severidad de los síntomas diurnos y el impacto de la enfermedad sobre la calidad de vida del paciente, y no la mera consideración de los índices de apnea-hipopnea durante el sueño, los que deben guiar la atención del paciente con sospecha de apneas del sueño.
Se revisan las complicaciones clínicas derivadas de las apneas del sueño.
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