To evaluate the efficacy of golimumab on severe and frequent recurrent anterior uveitis in patients with HLA-B27-positive ankylosing spondylitis. In this study, 15 eyes of 12 HLA-B27-positive AS patients with resistant anterior uveitis who received 50 mg of subcutaneous golimumab (Gol) per month due to frequent uveitis recurrences were analyzed retrospectively between May 2013 and October 2015. Assessment criteria were uveitis activity, the number of recurrence of uveitis, visual acuity, systemic corticosteroid, or other drug requirement for maintenance of remission of AU. Twelve patients (15 eyes) with HLA-B27-positive ankylosing spondylitis and anterior uveitis have been treated with golimumab 50 mg/month. Remission of uveitis was observed in 12 eyes out of 15. Malign hypertension developed in one subject after the second dose of golimumab therefore the treatment was stopped and this subject was excluded from the study. Median follow-up time was 11 months (interquartile range: 8-18). No uveitic reaction was seen except in the patient who stopped treatment. No topical or systemic steroid necessity was needed except in two cases with oral 4 mg systemic maintenance. Visual acuity was significantly increased (p = 0.002). Golimumab may be a new and effective choice for maintaining remission and the prevention of recurrences of severe, resistant anterior uveitis in patients with HLA-B27-positive ankylosing spondylitis.
Women with SS experience less satisfaction with sexual activity, which can be affected by age, vaginal dryness, physical pain, and impaired function due to the disease. Therefore, rheumatologists should pay attention to these symptoms and management.
In the present study, there was no difference in port-related severe complications between frequent and infrequent care groups during follow-up. However, the rate of thrombosis was slightly higher in the infrequent port care group.
Günümüz toplumunda akıllı telefonlar aracılığıyla kullanılan sosyal medya, özellikle üniversite öğrencileri arasında, günlük yaşamın vazgeçilmez bir parçası haline gelmiştir. Bu durum, beraberinde akıllı telefonlara olan bağımlılık sorunsalını da gündeme getirmekte ve bireyin kişilik özellikleri ile ilişkilendirilerek açıklanabileceği düşünülmektedir. Dolayısıyla bu araştırmada; öğrencilerin akıllı telefon bağımlılık düzeyleri ve sosyal medya kullanmalarının, Beş Faktör Kişilik özelliği ile ilişkisi incelenmiştir. Araştırma, Bitlis Eren Üniversitesinde öğrenim gören 343 öğrenci üzerinde gerçekleştirilmiştir. Veri toplamak amacıyla anket formu yöntemi kullanılmış olup, örneklem seçiminde basit tesadüfi örneklem yöntemi benimsenmiştir. Araştırma kapsamında, tanımlayıcı istatistiklerin yanı sıra, korelasyon, basit doğrusal regresyon, çoklu regresyon analizleri yapılmıştır. Yapılan analizler sonucunda öğrencilerin kişilik özellikleri ile akıllı telefon bağımlılığı ve sosyal medya kullanımları arasında istatistiki açıdan anlamlı ilişkiler bulunmuş, aynı zamanda sosyal medya kullanımının akıllı telefon bağımlılığını artırdığı tespit edilmiştir.
Nasal-type natural killer (NK)/T-cell lymphoma (NKTL) is a rare disease strongly associated with Epstein-Barr virus and is often localized to the upper aerodigestive tract at presentation. Extranodal NKTL may involve any extranodal site and disease beyond the nasal cavity is highly aggressive, with short survival time and poor response to therapy. Herein we present a 57-year-old male that had been treated with systemic chemotherapy and cranial radiotherapy for nasaltype NKTL in the palate with skin, right eye, and right peroneal nerve involvement. He was given salvage chemotherapy consisting of 3 cycles of ICE and his response to the therapy was satisfactory, except for persistent right drop foot. About 6 weeks later, the patient presented with bilateral total loss of vision and proptosis; therefore, DHAP chemotherapy was started. Unfortunately, after 1 cycle of the second salvage chemotherapy, he died due to severe fungal infection of the hard palate. Despite the fact that involvement of any extranodal site is possible, concurrent involvement of many systems in NKTL patients is unusual. Nasal-type NKTL has a poor prognosis, despite local radiotherapy and systemic chemotherapy. Physicians should be aware of this rare disorder than can only be diagnosed after extensive immunohistochemical studies.Conflict of interest:None declared.
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