A simple, mild, and efficient one-pot, three-component synthetic method has been developed for the preparation of α-aminophosphonates using phenylboronic acid as catalyst under solventfree conditions at 50°C. The process involves the reaction of carbonyl compounds (aldehydes or ketones) with benzylamine and dimethyl phosphite. A wide range of carbonyl compounds are compatible with this reaction, producing tertiary and quaternary αaminophosphonates in moderated to excellent yields in short time.
Aliphatic and aromatic aldehydes react with benzylamine and dimethyl phosphite within a short time to give the title compounds in good to excellent yields.
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