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Funding and support: By JACEP Open policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article as per ICMJE conflict of interest guidelines (see www.icmje.org). Nicholas W. Sterling and Felix Brann should be considered joint first author.

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Objective: Sensory deficits are important risk factors for delirium but have been investigated in single-center studies and single clinical settings. This multicenter study aims to evaluate the association between hearing and visual impairment or bi-sensory impairment (visual and hearing impairment) and delirium. Design: Cross-sectional study nested in the 2017 "Delirium Day" project. Setting and Participants: Patients 65 years and older admitted to acute hospital medical wards, emergency departments, rehabilitation wards, nursing homes, and hospices in Italy. Methods: Delirium was assessed with the 4AT (a short tool for delirium assessment) and sensory deficits with a clinical evaluation. We assessed the association between delirium, hearing and visual impairment in multivariable logistic regression models, adjusting for: Model 1, we included predisposing factors for delirium (ie, dementia, weight loss and autonomy in the activities of daily living); Model 2, we added to Model 1 variables, which could be considered precipitating factors for delirium (ie, psychoactive drugs and urinary catheters). Results: A total of 3038 patients were included; delirium prevalence was 25%. Patients with delirium had a higher prevalence of hearing impairment (30.5% vs 18%; P < .001), visual impairment (24.2% vs 15.7%; P < .01) and bi-sensory impairment (16.2% vs 7.5%) compared with those without delirium. In the multivariable logistic regression analysis, the presence of bi-sensory impairment was associated with delirium in Model 1 [odds ratio (OR) 1.5, confidence interval (CI) 1.2e2.1; P ¼ .00] and in Model 2 (OR 1.4; CI 1.1e1.9; P ¼ .02), whereas the presence of visual and hearing impairment alone was not associated with delirium either in Model 1 (OR 0.8; CI 0.6e1.2, P ¼ .36; OR 1.1; CI 0.8e1.4; P ¼ .42) or in Model 2 (OR 0.8, CI 0.6e1.2, P ¼ .27; OR 1.1, CI 0.8e1.4, P ¼ .63).

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Background: Patients with Coronavirus Disease 2019 (COVID-19) seem to be at high risk for venous thromboembolism (VTE) development, but there is a paucity of data exploring both the natural history of COVID-19 associated VTE and the risk for poor outcomes after VTE development. This investigation aims to explore the relationship between COVID-19 associated VTE development and mortality. Methods: A prospectively maintained registry of patients over 18 years of age admitted for COVID-19 related illnesses within an academic healthcare network between March and September 2020 was reviewed. Codes from the tenth revision of the International Classification of Diseases (ICD-10) for VTE were collected. The charts of those patients with an ICD-10 code for VTE were manually reviewed to confirm VTE diagnosis. Results: 2552 patients were admitted with COVID-19 related illnesses. 126 (4.9%) patients developed a VTE. A disproportionate percentage of patients of Black race developed a VTE (70.9% VTE versus 57.8% non-VTE, p=0.012). A higher proportion of patients with VTE expired during their index hospitalization (22.8% VTE versus 8.4% non-VTE, p<0.001). On multivariable logistic regression analysis, VTE was independently associated with mortality (OR 3.17; 95% CI, 1.9 to 5.2; p<0.001). Hispanic/Latinx ethnicity was associated with decreased mortality (OR 0.45; 95% CI, 0.21 to 1.00; p=0.049). Discussion: Hospitalized patients of Black race with COVID-19 were more prone to VTE development, and patients with COVID-19 who developed in-hospital VTE roughly nearly threefold higher odds of mortality. Further emphasis should be placed on optimizing COVID-19 anticoagulation protocols to reduce mortality in this high-risk cohort.