Human brain functional connectivity (FC) is often measured as the similarity of functional MRI responses across brain regions when a brain is either resting or performing a task. This paper aims to statistically analyze the dynamic nature of FC by representing the collective time-series data, over a set of brain regions, as a trajectory on the space of covariance matrices, or symmetric-positive definite matrices (SPDMs). We use a recently developed metric on the space of SPDMs for quantifying differences across FC observations, and for clustering and classification of FC trajectories. To facilitate large scale and high-dimensional data analysis, we propose a novel, metricbased dimensionality reduction technique to reduce data from large SPDMs to small SPDMs. We illustrate this comprehensive framework using data from the Human Connectome Project (HCP) database for multiple subjects and tasks, with task classification rates that match or outperform state-of-the-art techniques.
This paper studies change-points in human brain functional connectivity (FC) and seeks patterns that are common across multiple subjects under identical external stimulus. FC relates to the similarity of fMRI responses across different brain regions when the brain is simply resting or performing a task. While the dynamic nature of FC is well accepted, this paper develops a formal statistical test for finding change-points in times series associated with FC. It represents short-term connectivity by a symmetric positive-definite matrix, and uses a Riemannian metric on this space to develop a graphical method for detecting change-points in a time series of such matrices. It also provides a graphical representation of estimated FC for stationary subintervals in between the detected change-points. Furthermore, it uses a temporal alignment of the test statistic, viewed as a real-valued function over time, to remove inter-subject variability and to discover common change-point patterns across subjects. This method is illustrated using data from Human Connectome Project (HCP) database for multiple subjects and tasks.
We propose a manifold matching approach to generative models which includes a distribution generator (or data generator) and a metric generator. In our framework, we view the real data set as some manifold embedded in a highdimensional Euclidean space. The distribution generator aims at generating samples that follow some distribution condensed around the real data manifold. It is achieved by matching two sets of points using their geometric shape descriptors, such as centroid and p-diameter, with learned distance metric; the metric generator utilizes both real data and generated samples to learn a distance metric which is close to some intrinsic geodesic distance on the real data manifold. The produced distance metric is further used for manifold matching. The two networks are learned simultaneously during the training process. We apply the approach on both unsupervised and supervised learning tasks: in unconditional image generation task, the proposed method obtains competitive results compared with existing generative models; in super-resolution task, we incorporate the framework in perception-based models and improve visual qualities by producing samples with more natural textures. Both theoretical analysis and real data experiments guarantee the feasibility and effectiveness of the proposed framework.
Empirically multidimensional discriminator (critic) output can be advantageous, while a solid explanation for it has not been discussed. In this paper, (i) we rigorously prove that high-dimensional critic output has advantage on distinguishing real and fake distributions; (ii) we also introduce an square-root velocity transformation (SRVT) block which further magnifies this advantage. The proof is based on our proposed maximal p-centrality discrepancy which is bounded above by p-Wasserstein distance and perfectly fits the Wasserstein GAN framework with high-dimensional critic output n. We have also showed when n = 1, the proposed discrepancy is equivalent to 1-Wasserstein distance. The SRVT block is applied to break the symmetric structure of high-dimensional critic output and improve the generalization capability of the discriminator network. In terms of implementation, the proposed framework does not require additional hyper-parameter tuning, which largely facilitates its usage. Experiments on image generation tasks show performance improvement on benchmark datasets.
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