A mild strategy for Co(III)-catalyzed C(sp2)–H
cyanation of indoles was developed by using NCBLD as an electrophilic
cyanation reagent and 1-butyl-3-acetylimidazole ditrifluoromethylsulfonimide
([BAIM]NTf2) as an environmentally friendly and recyclable
solvent, and a series of 2-cyano products were obtained at room temperature.
Adopting this strategy, the unnatural nucleotide fragment precursor
of Remdesivir, which was a drug for COVID-19, was synthesized through
cyano transformation, further proving the practicability of this cyanation
method.
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