DNA-encoded
library (DEL) technology provided a powerful screening
platform for identifying potential bioactive small molecules with
high affinity to biologically interesting targets. Essential to a
successful DEL campaign are the drug-like small molecular moieties
of DNA-encoded libraries with expanded chemical space. Our laboratory
has been working on developing and producing novel DNA-encoded libraries
that complement current reported DELs. Herein, we demonstrated a general
set of DNA-compatible reactions that enable the preparation of pyrrole-based
DNA-encoded libraries in which the DNA tags are linked to the N position
of the pyrrole central core. Further diversification could be rapidly
incorporated into the pyrrole scaffold by robust iodination and Suzuki
coupling reactions.
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