No abstract

Our data indicate that propofol anesthesia promotes the restoration of disturbed excitatory and inhibitory neurotransmitter release in the hippocampus after PSD, similar to the beneficial effects of natural sleep. This finding suggests that propofol anesthesia may be a viable pharmacotherapeutic strategy for the treatment of certain sleep disorders that share similar mechanisms with PSD.

Pelvic organ cross-sensitization, also termed as viscero-visceral referred hyperalgesia, is a major contributor to painful endometriosis. Its underlying mechanism is poorly understood. Clinical and basic studies have shown that gabapentin, a drug that binds to the α2δ-1 subunit of voltage-dependent calcium channels (Cavα2δ-1), is effective in treating chronic visceral pain. Accordingly, we hypothesized that pelvic organ cross-sensitization in painful endometriosis is mediated by an upregulation of Cavα2δ-1 in the spinal cord. We examined if the dysregulation of spinal Cavα2δ-1 subunit may play an important role in the development of ectopic growths-to-colon cross-sensitization in a rat model of experimentally-induced endometriosis. Our findings suggest that there was an increased Cavα2δ-1 expression in the dorsal horn and an ectopic growths-to-colon cross-sensitization in female rats with established endometriosis. Intrathecal administration of gabapentin (300 μg) remarkably reduced the ectopic growths-to-colon cross-sensitization in rats with established endometriosis. Furthermore, intrathecal injection of Cavα2δ-1 antisense oligodeoxynucleotides reversed the ectopic growths-to-colon cross-sensitization and also normalized the upregulation of spinal Cavα2δ-1 expression in endometriosis rats. The current study suggests that the upregulation of Cavα2δ-1 in the spinal cord may contribute to pelvic organ cross-sensitization in painful endometriosis. Our study may provide a biological basis for selectively targeting this pathway to relieve viscero-visceral referred hyperalgesia in patients with painful endometriosis.

No abstract

In order to investigate the ecological environment of Tangshan offshore breeding area (in the north of Bohai Sea), water quality and phytoplankton were investigated and monitored in two consecutive years (2019 and 2020). To evaluate and analyze the water condition of the breeding area, we used the nutrition index (E), Nutritional status quality index (NQI), organic pollution assessment index (A), Biodiversity Index (H’) and Integrated environmental quality index (EQI). The result showed that the range of E was 0.01∼0.97 in May (2019), 0.14∼0.59 in August(2019), 0.25∼0.63 in December(2019), 0.04∼1.21 in August(2020); the range of A was 0.39∼1.33 in May(2019), 0.73∼1.16 in August(2019), 0.87∼1.19 in December(2019), -0.15∼2.33 in August(2020); the range of H was 0.84∼2.11 in May(2019), 1.07∼1.21 in August(2019), 1.92∼2.86 in December (2019), 0.71∼1.47 in August(2020). By calculation, EQI was 94.34 in 2019 and 100 in 2020. The results showed that the nutrient level of the culture area was generally low, and it was in poor nutrition state. The phytoplankton diversity in summer was better than that in spring and winter. The organic pollution degree of the water area was low, but the water quality was good. In conclusion, the environmental quality of aquaculture area was good, which could meet the requirements of functional area.

The genetics of pain: implications for perioperative pain management.

No abstract

In May and October 2017, 12 stations were set up in the Central Bohai Sea for fishery resources investigation. The results show that there are many dominant species in this area, and the inshore fishery resources are higher than those in the open sea because of the abundant nutrients from land, the high density of zooplankton and the food of swimming animals. In order to effectively protect the fishery resources in the Central Bohai Sea, this paper puts forward some suggestions, such as strengthening the protection propaganda, scientific and reasonable fishing, and strengthening the management of marine environment.