iRGD can significantly improve the tumor accumulation and tumor penetration of nanomaterials. However, it still remains unclear how far iRGD can enhance the properties of nanomaterials when its conjugation density...
Semiconductor
polymers have several featured advantages, such as
easily tunable optical properties, high light harvesting, good photostability,
etc. However, semiconductor polymers with desirable NIR-II absorbance
for the applications of both NIR-II photoacoustic (PA) imaging and
photothermal therapy (PTT) are still lacking. Herein, we synthesized
a donor–acceptor (D–A) type semiconductor polymer PTPTQ
with thiophene (TP) as the electron donor and thiadiazoloquinoxaline
(TQ) as the acceptor. PTPTQ had a brushlike topological structure
with two poly(ethylene glycol) (PEG) chains (2000 Da) in each repeating
unit. Such an intriguing structure endowed it with high hydrophilicity,
good biocompatibility, and prominent passive tumor targeting ability.
PTPTQ exhibited strong absorption in 600–1800 nm and good photostability.
Its photothermal conversion efficiency was determined to be about
41.36%, which rendered it excellent properties in NIR-II PA imaging
and PTT. By using PTPTQ as a PTT agent, the mouse tumor models can
be eradicated. Taken together, the overall properties of PTPTQ make
it promising as a tumor theranostic agent.
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