The antimicrobial peptides (AMPs) are a group of unique naturally occurring anti-microbial compounds with around 50 amino acids. It represents promising therapeutic agents to the infectious disease without concerning about drug resistance. However, commercial development of these peptides for even the simplest application has been hindered by the limitations of sources, instability, toxicity and bioavailability. To improve the properties of the artificial synthesized AMPs, the modification and design are the hotspots of the AMPs research. In fact, more than half of the known AMPs are naturally modified. In this review, two types of modification strategies, biochemical modification and chemical modification were summarized. Although, the chemical modification is versatile and direct, the manufacturing cost is greatly increased compared to the antibiotics. With the recent progress of the protein modification enzyme, the biochemical modification of the antimicrobial peptide followed by heterologous expression has great application prospects.
The environmental conditions affect the external insulation performance of power equipment. In order to study the physical characteristics of air discharge, the microscopic process of electron–molecule collision in the air based on the Boltzmann equation has been studied in this paper. The influence of humidity on the air gap insulation performance was also analyzed. The calculation results show that with the temperature 300 K and the pressure 1.0 atm, the electron energy distribution function and electron transport parameters varied with the air relative humidity. As the air relative humidity is increased by each 30%, the average electron energy decreases by about 0.2 eV, the reduced electron mobility decreases by about 0.25 × 1023 [1/(V·m·s)], the reduced electron diffusion coefficient decreases by about 0.2 × 1024 [1/(m s)], and the effective ionization coefficient decreases by about 4 × 10−24 m2. As the air relative humidity increases from 0% to 60%, the critical breakdown electric field increases by 1.22 kV/cm.
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