Background: The COVID-19 epidemic has been outbreak and even spread to the global. The whole medical system in the world is facing great challenges. As one of the main forces, nursing staff are at the highest risk. Their negative emotions and job burnout are worthy of attention. This study aims to investigate the status of burnout and anxiety among nurses during COVID-19 epidemic and analyze the influencing factors of burnout.Methods: A cross-sectional survey was conducted from February 19 to February 25, 2020. A total of 1011 nurses from Wuhan tertiary hospitals were distributed with the basic information questionnaire, Maslach Burnout Inventory - General Survey (MBI-GS) and State-Trait anxiety inventory (STAI). The number of final valid questionnaire was 885. The effective recovery rate was 87.5%. Linear regression analysis was performed to explore the influencing factors.Results: The mean score of three dimensions of MBI-GS was 11.50, 6.02, 24.47, respectively. The mean score of state anxiety was 45.52 and trait anxiety, 43.78. Anxiety was positively related to emotional exhaustion and cynicism, and negatively to personal accomplishment. The positive factors of burnout were personnel agency, 5 years or less work experience, living in hospital dormitory, Wuhan medical team, working more than 9 hours, and the best level of knowledge of COVID-19. And having no siblings, intermediate title, working in isolation wards, 3 and more night shifts per week, living in hotels, and having confirmed or suspected medical staff around were negative factors. Conclusions: From this study, the anxiety level among nurses during the COVID-19 is serious, however, the level of burnout is mild to medium. Managers should continue to pay attention to the negative emotions of nurses and related factors, and take interventions timely to stabilize the nursing team.

Background The coronavirus disease 2019 (COVID-19) epidemic has broken out and even spread globally. The healthcare system worldwide faces enormous challenges, and nurses are at the highest risk as one of the leading forces. It's worth paying attention to nurses' anxiety and job burnout. This study aimed to investigate nurses' levels of burnout and anxiety during the epidemic of COVID-19 and to analyze influencing factors of burnout. Methods A cross-sectional survey was conducted from 19 to 25 February 2020. Questionnaires such as the basic information questionnaire, Maslach Burnout Inventory-General Survey (MBI-GS), and State-Trait Anxiety Inventory (STAI) were used among 1011 nurses in Wuhan tertiary hospitals via the online survey. The final number of valid questionnaires was 885. The effective response rate was 87.5%. Results The average score of MBI-GS was 11.50, 6.02, 24.47, respectively. The average score for state anxiety was 45.52 and trait anxiety, 43.78. Anxiety was positively associated with emotional exhaustion and cynicism, and negatively related to personal accomplishment. The protective factors of burnout were personnel agency, five years or less work experience, living in hospital dormitory, Wuhan medical team, working time exceeding 9 h, and the best knowledge of COVID-19. The absence of siblings, median job title, working in isolation wards, three or more night shifts per week, living in hotels, and being surrounded by confirmed or suspected medical staff were all negative factors. Conclusions Nurses had high anxiety levels during the COVID-19 period, but the level of burnout was mild to moderate. Managers should continue to pay attention to nurses' psychological state and related factors and intervene to stabilize the nursing team.

Berberine, with a variety of pharmacological effects, is a quaternary ammonium salt from the group of isoquinoline alkaloids, which mainly exist in ranunculaceae, rutaceae and berberidaceae. Now some literatures report that berberine derivatives have more accordingly physiological activity than berberine and enlarge the application fields of berberine. In this paper, the biological and chemical synthesis and the biological activity of berberine and its derivatives are reviewed, as well as the prospects of a new synthetic strategy of berberine derivatives.