A direct and efficient approach to the synthesis of monofluoromethylthioesters from aldehydes has been developed. The synthetic method features mild reaction conditions, good tolerance of functional groups, a broad substrate scope, and especially no metal involved in the reaction. The approach has the potential to be an important tool for the late‐stage functionalization of advanced synthetic intermediates, and may find many applications in medicinal chemistry.magnified image
An efficient highly regioselective C5-H direct iodination of indoles is reported herein for the first time. Due to the versatility of aryl iodides, the method offers a general and practical...
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