We report metallurgy on the nanoscale to generate metal nanoparticles and their simultaneous patterning in a single step. This is achieved by the self-reduction of porous metal–organic framework crystals using nanosecond pulsed laser irradiation. Metal nanoparticles of Fe, Co, Ni, Cu, Zn, Cd, In, Bi, and Pb with uniform sizes (controllable between 3 to 200 nm) and gaps (as narrow as 2 nm) are produced by nine different metal–organic frameworks, where atomically dispersed non-noble metal ions are reduced and gathered across the pores. The instant light absorption and cooling at local positions by a laser allows for precise and efficient patterning of metal nanoparticles. This new method is suitable for device fabrication at a speed of 15 mm2 s–1 on glass, consuming only 1.5 W of power. A large variety of metal nanoparticle three-dimensional architectures are demonstrated, among which one architecture exhibits an enhanced plasmonic effect homogeneously across the entire pattern for the detection of molecules at an extremely low concentration (10–12 M). These architectures are extremely stable under air and humidity during production, use, and storage, without altering the oxidation state, for 6 months.

Surface-enhanced Raman scattering (SERS) and magnetic resonance imaging (MRI)-guided phototherapy are new breakthroughs in cancer therapeutics due to their complementary advantages, such as enhanced imaging spatial resolution and depth.

The unique “tip spots” can simultaneously enhance SERS and the photothermal effect, facilitating label-free SERS intracellular imaging during cell apoptosis.

High-throughput optical labeling technologies have become increasingly important with the growing demands for molecular detection, disease diagnosis, and drug discovery. In this thought, a series of CN-bridged coordination polymer encapsulated gold nanoparticles have been developed as a universal and interference-free optical label through a facile and auxiliary agent-free self-assembly route. Moreover, surface-enhanced Raman scattering (SERS) emissions of CN-bridge can be tuned flexibly by simple replacement of Fe2+/Fe3+ with other metal ions relying on the synthesis of three Prussian blue analogues encapsulated gold nanoparticles (Au@PBA NPs). Thus, three distinct Raman frequencies have been acquired, which merely replaced the metal irons. On the basis of the potential supermultiplex optical label, space-confined surface-enhanced Raman scattering (SERS) emissions have been realized. Relying on “Abbe theorem”, the focused laser allows the pure and single triple bond-coded SERS emissions to be combined into a unique and independent output, so-called “combined SERS emission” (c-SERS), if the Au@PBA NPs were confined into one micrometer-scale object. This study demonstrated c-SERS may simultaneously provide 2 n – 1 optical labels only using n single emissions in the Raman-silent region for micrometer-size objects.

Materials with surface wrinkles at a micro/nanoscale possess extraordinary fascinating properties, and various techniques have been employed to create controllable wrinkles. Herein, natural polysaccharide was used to construct the surface wrinkled microsphere with controllable wrinkling patterns. A robust microsphere with an average size of about 55 μm fabricated from chitosan in alkali/urea aqueous solution was swelled and then coated orderly by introducing rigid silver nanoparticles (Ag NPs) with an average size of about 5 nm as the shell onto the surface through electrostatic layer-by-layer (LBL) self-assembly followed by deswelling, resulting in a surface wrinkled microsphere. The significant difference in the swelling behaviors between the stiff Ag shell and swelled chitosan microsphere could generate enough driving forces to form 3D micro- and nanoscale wrinkling surface topography. The surface wrinkled microspheres exhibited the hierarchically porous structure and hydrophobicity, and the topographical patterns could be adjusted by controlling the thickness of the Ag NP layer to achieve the sizes of wrinkling ranging from 60 to 300 nm. It was demonstrated that the wrinkled microspheres were superior as 3D surface-enhanced Raman spectroscopy (SERS) substrates, in which the wrinkled structure with spatial periodicity was proved to be effective for enhancing the SERS signal. The microsphere with controllable wrinkled surface topography could be applied to be a miniature 3D device, which promises potential technological applications in various areas.