Background: Dimeric ␣␤-tubulin regulates mitochondrial respiration by blocking VDAC. Results: The on-rate of tubulin binding to VDAC varies more than 100-fold depending on the lipid type. Conclusion: VDAC blockage by tubulin involves a crucial step of tubulin interaction with the membrane. Significance: VDAC-tubulin binding is a new example of lipid-controlled protein-protein interactions that contribute to mitochondrial metabolism regulation.

No abstract

No abstract