Abstract:In this article we suggest a new concept for cell destruction based upon manipulating magnetic nanoparticles (MNPs) by applying external, low frequency alternating magnetic field (AMF) that oscillates the particles, together with focused laser illumination. Assessment of temperature profiles in a head and neck squamous cell carcinoma sample showed that cells with MNPs, treated with AMF (3 Hz, 300 mW) and laser irradiation (30 mW), reached 42°C after 4.5 min, as opposed to cells treated with laser but without AMF. Moreover, a theoretical model was developed to assess the overall theoretical temperature rise, which was shown to be 50% lower than the experimental temperature. Furthermore, we found that the combination of laser irradiation and AMF decreased the number of live cells by ~50%. Thus, the concentrated assembly of laser heating with AMF-induced MNP oscillations leads to more rapid and efficient cell death. These results suggest that the manipulated MNP technique can serve as a superior agent for PTT, with improved cell death capabilities. References and links1. X.-L. Yue, F. Ma, and Z.-F. Dai, "Multifunctional magnetic nanoparticles for magnetic resonance image-guided photothermal therapy for cancer," Chin. Phys. B 23(4), 044301 (2014). 2. X. Huang, I. H. El-Sayed, W. Qian, and M. A. El-Sayed, "Cancer cells assemble and align gold nanorods conjugated to antibodies to produce highly enhanced, sharp, and polarized surface Raman spectra: a potential cancer diagnostic marker," Nano Lett. 7(6), 1591-1597 (2007). Loening, and P. Wust, "Thermotherapy of Prostate Cancer Using Magnetic Nanoparticles: Feasibility, Imaging, and Three-Dimensional Temperature Distribution," Eur. Urol. 52(6), 1653-1662 (2007). 12. T. Roose, "Challenges in imaging and predictive modeling of rhizosphere processes," Plant Soil 407, 9-38 (2016). 13. C. C. Berry, "Progress in functionalization of magnetic nanoparticles for applications in biomedicine," J. Phys. D Appl. Phys. 198, 22 (2009 Motiei, and R. Popovtzer, "A challenge for theranostics: is the optimal particle for therapy also optimal for diagnostics?" Nanoscale 7(37), 15175-15184 (2015). 17. T. Reuveni, M. Motiei, Z. Romman, A. Popovtzer, and R. Popovtzer, "Targeted gold nanoparticles enable molecular CT imaging of cancer: an in vivo study," Int. J. Nanomedicine 6, 2859-2864 (2011). 18. V. Adi, R. Arkady, B. Yevgeny, D. Hamootal, P. Rachel, and Z. Zeev, "manipulated magnetic nano particles for photonic biomedical mapping," Nanosci. Nanotechnol. Lett. 7, 1-9 (2015). stabilized iron oxide magnetic nanoparticles," J. Nanopart. Res. 9(5), 959-964 (2007).
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