2Thus far, the translation of promising results from preclinical stroke research into effective clinical therapy has not met with success (1). Among the numerous possible reasons for this failure, quality problems in some of the basic research or preclinical studies have to be considered. False-positive results, inflated effect sizes, and marginal reproducibility may have overestimated or even affected the potential of novel stroke therapeutics (2). Systematic reviews have found quantitative evidence that low study quality may have introduced a bias into preclinical stroke research (3,4,5). As opposed to many other causes of the 'translational roadblock', study quality is fully under the control of the researcher, and thus a prime target for improvement. Increasingly, funding bodies and review boards overseeing animal experiments are taking a proactive stance, and demand auditable measures of quality control in preclinical research (6). The Stroke Therapy Academic Industry Roundtable (STAIR) recently updated its recommendations for the evaluation of preclinical data on neuroprotective drugs (7) to include good laboratory practice (GLP) issues (8).Monitoring, auditing, and standard operating procedures (SOPs) are key elements of quality control in randomized clinical trials (RCTs). It has been proposed that experimental stroke research adapt some of the tools used in clinical stroke research. In particular, stroke laboratories should set up and publish their SOPs (e.g., on their institutional websites), and guarantee that their studies adhere to these standards (9). This is all the more important, as a certain portion of their experiments, evaluations, etc. are not performed by professionals, but rather by students in training who are unaware of these issues.A standard operating procedure (SOP) is a set of instructions with the force of a directive covering those features of operations that lend themselves to a definite or standardized procedure without loss of effectiveness. The primary purpose of an SOP in experimental stroke research is to guide and standardize working procedures in order to ensure data reliability and integrity. It is crucial that researchers, students and technicians read and follow Nature Precedings :
Recently, systematic reviews have found quantitative evidence that low study quality may have introduced a bias into preclinical stroke research. Monitoring, auditing, and standard operating procedures (SOPs) are already key elements of quality control in randomized clinical trials and will hopefully be widely adopted by preclinical stroke research in the near future. Increasingly, funding bodies and review boards overseeing animal experiments are taking a proactive stance, and demand auditable quality control measures in preclinical research. Every good quality control system is based on its SOPs. This article introduces the concept of quality control and presents for the first time an SOP in experimental stroke research.
2Thus far, the translation of promising results from preclinical stroke research into effective clinical therapy has not met with success (1). Among the numerous possible reasons for this failure, quality problems in some of the basic research or preclinical studies have to be considered. False-positive results, inflated effect sizes, and marginal reproducibility may have overestimated or even affected the potential of novel stroke therapeutics (2). Systematic reviews have found quantitative evidence that low study quality may have introduced a bias into preclinical stroke research (3,4,5). As opposed to many other causes of the 'translational roadblock', study quality is fully under the control of the researcher, and thus a prime target for improvement. Increasingly, funding bodies and review boards overseeing animal experiments are taking a proactive stance, and demand auditable measures of quality control in preclinical research (6). The Stroke Therapy Academic Industry Roundtable (STAIR) recently updated its recommendations for the evaluation of preclinical data on neuroprotective drugs (7) to include good laboratory practice (GLP) issues (8).Monitoring, auditing, and standard operating procedures (SOPs) are key elements of quality control in randomized clinical trials (RCTs). It has been proposed that experimental stroke research adapt some of the tools used in clinical stroke research. In particular, stroke laboratories should set up and publish their SOPs (e.g., on their institutional websites), and guarantee that their studies adhere to these standards (9). This is all the more important, as a certain portion of their experiments, evaluations, etc. are not performed by professionals, but rather by students in training who are unaware of these issues.A standard operating procedure (SOP) is a set of instructions with the force of a directive covering those features of operations that lend themselves to a definite or standardized procedure without loss of effectiveness. The primary purpose of an SOP in experimental stroke research is to guide and standardize working procedures in order to ensure data reliability and integrity. It is crucial that researchers, students and technicians read and follow Nature Precedings :
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.