Background Mobile applications such as personalized tracking tools and food choice aids may enhance weight loss programs. We developed and assessed client preferences for the content, user interface, graphics, and logic flow of a mobile application, and evaluated its validity for tracking compliance with weight control and making healthy and sustainable food choices. Methods Our four-stage study comprised formative research, application development, acceptance assessment, and validity. The formative research included literature reviews and six focus groups with 39 respondents aged 19–64 years at high risk for obesity. The development stage included programmer selection, defining application specifications, design, and user interface. Prototype acceptability was assessed with 53 respondents who graded 17 features of content, graphic design, and application flow (ranked as good, moderate, and poor). A feature was considered to have "good" acceptance if its mean response was higher than the mean of overall responses. The validity was assessed in 30 obese women using Bland–Altman plots to compare results from dietary intake assessment from the application to conventional paper-based methods. Results The application was named as EatsUp®. The focus group participants defined the key requirements of this app as being informative, easy, and exciting to use. The EatsUp® core features consisted of simple menu recommendations, health news, notifications, a food database, estimated portion sizes, and food pictures. The prototype had a "good" overall acceptance regarding content, graphics, and flow. Fourteen out of 17 parameters were graded as "good" from > 70% of respondents. There was no significant difference between the rated proportions for content, graphics, and app flow (Kolmogorov–Smirnov Z-test, p > .05). The agreement using the Bland–Altman plots between EatsUp® and the paper-based method of measuring food intake was good, with a mean difference of energy intake of only 2.63 ± 28.4 kcal/day (p > 0.05), well within the 95% confidence interval for agreement. Conclusions The EatsUp® mobile application had good acceptance for graphics and app flow. This application can support the monitoring of balanced and sustainable dietary practice by providing nutritional data, and is comparable with conventional dietary assessment tools, and performed well in tracking energy, macronutrient, and selected micronutrients intakes. Trial registration NCT03469869. The registration date was March 19, 2018.

Latar belakang. Proses pertumbuhan dan perkembangan anak amatlah penting. Mengetahui secara dini gangguan perkembangan diharapkan dapat memberikan manfaat yang lebih baik. Berbagai metode untuk mendeteksi gangguan perkembangan pada anak, antara lain metode Capute Scales (CAT/CLAMS) adalah uji tapis spesifik menilai kemampuan komunikasi dan fungsi kognitif untuk anak berusia 0-36 bulan.Tujuan. Mengetahui hubungan antara beberapa faktor risiko terjadinya gangguan perkembangan dengan status perkembangan anak usia 0-36 bulan.Metode. Desain penelitian yang digunakan adalah potong lintang. Pemeriksaan dilakukan terhadap 75 anak di RW 03, Kelurahan Pulo Gadung menggunakan skrining CAT/CLAMS dan pertanyaan tersebut diajukan kepada ibu. Pengambilan sampel dilakukan secara purposive sampling.Hasil. Diperoleh status perkembangan normal sebesar 84%, suspek gangguan perkembangan 13,3%, gangguan komunikasi 3%, dan tidak ditemukan subjek yang mengalami retardasi mental. Sejumlah faktor risiko yang diteliti adalah jenis kelamin, pemberian ASI eksklusif, urutan anak, usia ibu saat hamil, pendidikan ibu atau pengasuh, jumlah anak, jumlah penghasilan keluarga dan bentuk keluarga. Secara statistik tidak ada faktor risiko yang bermakna.Kesimpulan. Jenis kelamin laki-laki, tidak mendapat ASI eksklusif, ibu dengan tingkat pendidikan tinggi, jumlah anak lebih dari dua, bentuk keluarga inti mempunyai kecenderungan lebih besar menderita status perkembangan yang tidak normal. Namun tidak dapat dibuktikan hubungan bermakna secara statistik antara faktor-faktor yang diteliti dengan status perkembangan anak.

Sepsis has been accounted for various burdens worldwide, especially in critically ill patients. This could eventually lead to inflammatory response, provocation ischemia and lactic acidosis. On the other hand, thiamine was suggested as a coenzyme which could improve the outcome of those patients. Thus, we conducted an evidence-based case study with research on PubMed, ProQuest, and Scopus using a search strategy focusing on RCT or cohort study on thiamine supplementation/level towards the outcome of critically ill patients with sepsis. We found three articles eligible for review after full-text assessment. Articles were appraised using the University of Oxford’s tools for critical appraisal. It was known that all studies were good in terms of validity and applicability. This study showed that thiamine supplementation could improve lactate clearance and reduce mortality risk, moreover, thiamine deficiency could increase the risk of lactate acidosis. However, a high level of thiamine was associated with a high level of lactate in patients with liver failure. Therefore, thiamine supplementation could be recommended for critically ill patients with sepsis and normal liver function. Further research, such as RCT or systematic review on thiamine supplementation for age groups to make this study more applicable.