Twenty-two patients completed the entire length of the study. Imiquimod 5% was superior to vehicle in reducing DIET scores at 3, 6, 9, and 12 months (p < .05). Induration demonstrated the greatest response. Histologic evaluation showed significant improvement or resolution of disease. However, no ultrasonographic differences were found in dermal and hypodermal thicknesses between the treatment and vehicle groups (p > .05). Adverse effects were minimal and well tolerated.
Background: Lichen planus (LP) is a condition with many clinical variants that can be quite varied in their presentation.Objective: We report a case of a 60-year-old woman who presented with a very unusual palmoplantar eruption characterized by violaceous pustule-like papules that was subsequently diagnosed as LP.Methods: The above case is reported, along with biopsy results. The patient was subsequently treated with a combination of topical corticosteroids and oral acitretin, and her clinical course was followed.Results: The eruption responded dramatically to our combination treatment and resolved by the 2-month follow-up.Conclusion: Palmoplantar LP is a rare variant of LP that bears little resemblance to its classic LP. This condition responds well to a combination of potent topical corticosteroids and oral acitretin.Anté cé dents: Les variantes cliniques du lichen planus (LP) sont nombreuses et se pré sentent sous diverses formes.Objectif: Rapporter le cas d'une femme â gé e de 65 ans qui souffre d'une é ruption palmoplantaire trè s inusuelle, caracté risé e par des papules violacé es ressemblant à des pustules, diagnostiqué es plus tard comme LP.Mé thodes: Nous rapportons le cas avec les ré sultats de la biopsie. La patiente a reç u un traitement combiné de corticosté roïdes topiques et d'acitré tine par voie orale. Son é volution clinique a é té suivie.Ré sultats: L'é ruption a bien ré pondu au traitement combiné et, au suivi 2 mois plus tard, avait disparu.Conclusion: Le LP palmoplantaire est une variante rare du LP qui ressemble peu au LP classique. Cette condition ré pond bien à un traitement combiné de corticosté roïdes topiques actifs et à l'acitré tine par voie orale.
Lupus vulgaris can occur in a locus minoris resistentiae; local trauma and possibly other factors, such as increased temperature, topical corticosteroids, and the virulence of the infecting strain, may facilitate the growth of Mycobacterium tuberculosis present at a locus minoris resistentiae as a result of a silent bacillemia.
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