Couples and relationship education (CRE) programs indicate pos-itive results for low-income couples who attend. However, most studies examined relationship satisfaction or communication patterns, with few addressing the influence of CRE on parental alliance and even fewer examining parental alliances for those who attend couples-level and individual-level programs. Thus, we examined changes in parental alliance for participants who attended CRE individually (n = 182) and with their partner (n = 190). Participants who attended couples level CRE with a partner reported significant parental alliance improvements at post-assessments, while those who attended individual level CRE independently did not.

Program for the past three and a half years, she is passionate about sociotechnical interfaces and human impacts in engineering. Her involvement with the Society of Women Engineers increased her awareness of the challenges facing female engineering students, both at the university level and as they pursue careers in industry. Graduating this December, she hopes to retain this knowledge for the benefit of herself and other women engineers as she pursues an industry career.

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In this report, we demonstrated a novel technique to prepare genistein (GEN) MePEG-PLGA copolymer micelles. Initial stability and pharmacokinetic behavior in rats after intravenous administration were investigated. The micelles were prepared by modified self-emulsifying solvent evaporation method. The morphology, encapsulation efficiency, drug loading, particle size and Zeta potential were investigated. The release behavior was investigated by dynamic membrane dialysis technique. The micelles were stored in a refrigerator at 4 °C, and samples were taken after 1 d, 10 d, 1 month, 3 months, and 6 months, and the encapsulation efficiency and drug loading were examined. The GEN micelles were injected into the tail vein of healthy rats. The blood concentration of GEN in rats was determined by HPLC. The plasma concentration data was processed by DAS 2.0 software. The main pharmacokinetic parameters were statistically analyzed by SPSS 17.0 software. Results The encapsulation efficiency of the prepared micelles was (84.43 +/-2.93) %, the drug loading was (2.63 +/-0.91) %, and the particle size was (63.75 +/-4.12) nm. The release behavior of GEN micelles was in line with the Weibull model. The 6-month leakage rate of GEN micelles was 2.45%, and the drug loading decreased by 0.18%. The main pharmacokinetic parameters AUC0-t after GEN micelles and GEN emulsion 40 mg·kg -1 were injected into the tail vein of rats. They were (99.46 +/-4.77) mg·L -1 ·h and (57.51 +/-1.37) mg·L -1 ·h, and t1/2 were (7.48 +/-1.15)h and (4.95 +/-1.15)h, respectively, and Cmax was (16.03 +/-1.20) mg·L -1 and (16.73 +/-1.10) mg·L -1 , CL are (0.36 +/-0.02) L·h -1 ·kg -1 and (0.67 +/-0.02)L·h -1 ·kg -1 .