Corticosteroids are commonly used in lymphoma patients, and findings in favor of esophageal involvement in 18F‐FDG PET‐CT should be considered suspicious and definitely be confirmed by biopsy. We describe a 58‐year‐old lady with diffuse large B‐cell lymphoma and central nervous system involvement having an increased metabolism in the distal esophagus with 18F‐FDG PET/CT, which was consistent with esophageal candidiasis, most probably due to prolonged use of dexamethasone. Esophageal candidiasis can be misdiagnosed as malignancy with a high SUVmax and may lead to difficulties while managing these patients.
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