Background: Psoriasis is a chronic and relapsing inflammatory disease of the skin, characterized by the presence of well-defined erythematous plaque covered by silvery-white scales. Methotrexate is a folic acid antimetabolic for psoriasis therapy and given systemically so unexpected effects can occur. Purpose: To evaluate the side effects of methotrexate as therapy in psoriasis. Methods: The descriptive research based on the medical record of psoriasis patients who were treated for hospitalization on at Kemuning I and II ward Dr. Soetomo General Academic Hospital Surabaya during the period January 2017 – December 2018. The sampling method used was total sampling. Result: Twenty two psoriasis patients receiving methotrexate therapy with the dose of methotrexate is 10-15 mg once weekly, there were 4.5% low erythrocyte level, 27.3% high leukocyte level, 13.6% high thrombocyte level, 18.2% high SGOT level, 22.8% high SGPT level, 18% nausea, 9.1% vomiting, 4.6% headache, and 4.6% shortness of breath. Conclusion: Methotrexate for psoriasis therapy may cause several side effects even not the severe ones, therefore careful dosing and side effect monitoring are necessary.
Crab, a fishery product commodity, is very likely to be contaminated by heavy metals from the aquatic environment due to chemical pollution. The analysis of lead-heavy metal content in canned crabs used a method that referred to SNI 2354.5: 2011 starting from sample preparation to reading the sample using the Atomic Absorption Spectrophotometry (AAS) instrument. The purpose of testing with AAS was to determine the levels of heavy metal Pb in samples of canned crab products carried out at BPMHP Semarang. The analysis results show that the Pb content of the sample of canned crab products is below the threshold of less than 0.5 mg/kg (SNI 6929: 2016) so that the product is safe for consumers. The residual content of heavy metals in a processed fishery product must be minimized to ensure the community’s continuity of healthy food.
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