Background/Objectives: Most insulin-requiring diabetes patients in Ethiopia have an atypical form of the disease, which resembles previous descriptions of malnutrition-related diabetes. As so little is known about its aetiology, we have carried out a case-control study to evaluate its social and nutritional determinants. Subjects/Methods: Men and women with insulin-requiring diabetes (n ¼ 107), aged 18-40 years, were recruited in two centres, Gondar and Jimma, 750 km northwest and 330 km southwest of the capital, Addis Ababa, respectively. Controls of similar age and sex (n ¼ 110) were recruited from patients attending other hospital clinics. Results: Diabetes was strongly associated with subsistence farming, odds ratio ¼ 3.5 (95% confidence interval: 1.5-7.8) and illiteracy/low levels of education, odds ratio ¼ 4.0 (2.0-8.0). Diabetes was also linked with a history of childhood malnutrition, odds ratio ¼ 5.5 (1.0-29.0) the mother's death during childhood, odds ratio ¼ 3.9 (1.0-14.8), and markers of poverty including poorer access to sanitation (P ¼ 0.004), clean water (P ¼ 0.009), greater overcrowding (P ¼ 0.04), increased distance from the clinic (P ¼ 0.01) and having fewer possessions (P ¼ 0.01). Compared with controls, people with diabetes had low mid upper arm circumference, body mass index (BMI) and fat/lean body mass (Po0.01). In addition, men with the disease tended to be shorter, were lighter (P ¼ 0.001), with reduced sitting height (P ¼ 0.015) and reduced biacromial (P ¼ 0.003) and bitrochanteric (P ¼ 0.008) diameters. Conclusions: Insulin-requiring diabetes in Ethiopia is strongly linked with poor education and markers of poverty. Men with the disease have associated disproportionate skeletal growth. These findings point towards a nutritional aetiology for this condition although the nature of the nutritional deficiency and its timing during growth and development remains obscure.

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