BackgroundAnti-CCP antibodies are known to be related to more erosive disease in rheumatoid arthritis (RA). In recent years these antibodies are found to be increased in chronic obstructive pulmonary disease, liver disease, autoinflammatory diseases and cigarette smoking as well.ObjectivesIn this study we searched whether additional factors such as lung, thyroid, liver problems and smoking had any contribution to anti-CCP levels in RA patients.MethodsOne hundred and thirteen RA patients who followed up in our rheumatology outpatient clinics participated in the study. In addition to demographic features, pulmonary function test results, anti thyroglobulin (anti TG ab) and anti thyro peroxidase (anti TPO ab) antibodies, hepatitis markers, erythrocyte sedimentation rate (ESR), C- reactive protein, rheumatiod factor (RF) and anti- CCP levels were evaluated.ResultsMean values of the parameters were as follows: age of the patients: 54.76±11.56; disease duration: 10.9±7.2 years, forced expiratory volume 1: 79.5±21.33, forced vital capacity: 81.85±16.73. Levels of anti TG ab was high in 9.7% and that of anti TPO ab was high in 18.6% of the patients. 10% of the patients were Hepatitis B carrier. 72.6% of the patients were smoking cigarette. We divide the patients into 2 groups according to anti- CCP levels (higher or lower then 60 units). We found statistical significant difference in anti TG ab levels (p: 0.04), RF levels (p: 0.00) and ESR (p: 0.001).ConclusionsIt is well known that RF and ESR levels are related with anti- CCP levels, in addition to these we found anti TG antibodies could also increase anti -CCP levels. It is necessary to make studies with larger samples for more precise decisions.Disclosure of InterestNone declared
BackgroundFear avoidance behavior which is caused by painful injury resulting precision and extreme fear is defined as kinesiophobia. Rheumatoid arthritis (RA) is a chronic, inflammatory and systemic disease with symmetrical arthritis and visceral involvement. Ankylosing spondylitis (AS) is a chronic, inflammatory disease with involvement of the spine or peripheral joints.ObjectivesIn our study, we aimed to evaluate the relationships between kinesophobia and disease activity, quality of life (QoL), level of physical activity and emotional status in RA and AS patients.MethodsWe included 42 patients with RA (8 males-M, 34 females-F) (group 1), 49 patients with AS (34 M, 15 F) (group 2) and 29 healthy controls (9 M, 20 F) (group 3) in our study. The QoL was assessed using the health assessment questionnaire (HAQ), kinesiophobia was assesed with Tampa scale of kinesiophobia (TSK), pain was assesed with visual analog scale (VAS), fatigue was assesed with VAS and emotional status was assesed with Beck depression inventory (BDI). Disease activity was assesed with Bath ankylosing spondylitis disease acitivity index (BASDAI) and functional status was assesed with Bath ankylosing spondylitis functional index (BASFI) in patients with AS. Disease activity was assesed with DAS28 in patients with RA.ResultsThe mean age was 46.2 in group 1, 43.2 in group 2 and 40.17 in group 3. There was no difference among groups with respect to mean age (p>0.05). Kinesiophobia was present in 37 patients in group 1, 22 patients in group 2 and 7 patients in group 3. Statistically significant differences were found among groups with respect to the number of patients with kinesiophobia and to mean scores of pain intensity, fatigue, HAQ and BDI (p<0,05-<0,001). Patients with RA had higher rates of kinesiophobia than patients with AS and healthy controls (p=0.001, p=0,001). Patients with RA had worser scores than patients with AS and healthy controls. Patients with AS had worser scores than healthy controls. In patients with RA and AS, kinesiophobia is associated with pain severity, fatigue, emotional status and QoL.Table 1.Baseline features of the patients of AS and RA and healthy controlsGroup 1Group 2Group 3 Age46,2±11,4743,2±10,7340,17±7,77Gender (F/ M)34/815/3420/9VAS*47,02±24,4232,44±26,751,72±4,68TKS**44,73±7,2636±12,0329,58±9,37Fatigue (VAS)†55,47±24,3136,93±27,7037,93±20,59HAQ‡0,73±0,830,43±0,410,06±0,19BDI§14,17±9,4912,23±9,635,25±6,13*p=0.008 between group 1 and 2; p<0.001 between group 2 and 3; p<0.001 between group 1 and 3. **p<0.001between group 1 and 2; p=0.023 between group 2 and 3; p<0.001 between group 1 and 3. †p<0,05 between group 1 and 2; 2 and 3; 1 and 3. ‡p=0.039 between group 1 and 2; p=0.021 betwen group 2 and 3; p<0.001 between group 1 and 3. §p>0.05 between group 1 and 2; p=0.004 betwen group 2 and 3; p<0.001 between group 1 and 3.ConclusionsIn our study, patients with RA and AS had higher rates of kinesiophobia. We found that kinesiophobia was related with pain severity, fatigue, depression, disease activity and QoL of t...
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