Seven novel imidazole and thiazole derivatives of diphos-type ligands are presented. They are of the general structure R2P(CH2)(2)PR2, where R is imidazol-2-yl (1), 1-methylimidazol-2-yl (2), 1-methyl-benzimidazol-2-yl (3), 1-methylimidazol-5-yl (4), 2-isopropylimidazol-4(5)-yl (5), thiazol-2-yl (6), benzothiazol-2-yl (7), thiazol-4-yl (8) or thiazol-5-yl (9). Syntheses involved direct metallation or halogenmetal exchange reactions. Their solubility, especially in aqueous solution, is strongly dependent on the nature of the substituents as is their partition coefficient log D. The crystal structures of compounds 2, 3, 7a and 9 as well as the structure of the rhodium complex (2)(2) , Corinna Wetzel [a] , Melanie Bongartz [a] , Anna-Louisa Noffke [a] and Bernhard Spingler
The tetranuclear ruthenium arene compound [(cym)4Ru4(2)Cl6]Cl2 (3) (cym = 6-p-cymene, 2 = 1,2-bis(di-N-methylimidazol-2-ylphosphino)ethane) was prepared and characterised by one-and twodimensional NMR techniques. Its cytotoxicity against four different cell lines was determined and, with an approximate IC50 of >100 M 3 can be regarded as non-toxic. Its partition coefficient in n-octanol/water (log D7.4) was also determined. The structures of complex 3 as well as of the related compound [(cym)2Ru2(4)Cl2]Cl2 (5) (4 = 1,2-bis(di-N-methylimidazol-2-ylphosphino)ethane dioxide) were determined by single crystal structure analysis. Upon oxidation in protic solvents, ligand 2 shows P-C bond cleavage reactions to yield P,P-bis(N-methylimidazol-2-yl)ethylene diphosphinic acid (6). [ ‡] X-ray structure analysis.
KeywordsImidazolylphosphanes, Phosphane Ligands, PN Ligands, Ruthenium
AbstractThe tetranuclear ruthenium arene compound [(cym) 4 Ru 4 (2)Cl 6 ]Cl 2 (3) (cym = η
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