The effect of the ethanolic extract Khaya senegalensis on some biochemical parameters was tested in rabbits with normal glucose and glucose overload. Phytochemical screening after three batches of 6 rabbits race (TBD) were treated with the extract in oral doses of respectively 10, 25 and 50 mg/kg body weight for 30 days; three other groups receiving respectively these doses of the extract were placed under a priori temporary overload of glucose; a control group received instead distilled water treatment. Blood glucose, triglycerides and total cholesterol were measured by spectrophotometry and weight gain of the animals was performed at the beginning of the experiment and every 2 weeks during the study period. The phytochemical screening revealed the presence of polyphenolic compounds (majority) of saponins of anthracene derivatives and steroids in the extract. The test results indicate that under the dose of 50 mg/kg body weight (BW) there was a significant decrease (p < 0.05) in blood glucose after 24 hours. The extract had no effect on the lipid profile or body weight of rabbits.
Background: Increasing the use of traditional therapy is an obvious reality in some country. The bark of Khaya senegalensis is suspected to treat diabetes. That is what this type of work is started. Aims & Objective: The aim of this work is to test the effect of total Khaya senegalensis barks extracts on the hepatic liberation of glucose in vitro. Materials and Methods: The dried extracts obtained from barks powder had been prepared at concentrations of 0, 2, 5, 10 and 20 µg/L and applied on fragments of mice Wistar isolated liver, kept in Mack-Ewen solution. After incubation at 37°C in oven, glucose level in the solution had been measured by spectrophometer, using GOD-PAP ® regent, for each extracts concentration at the times T=0, 10, 20, 30, 40, 50 and 60 minutes. Results: Glucose level in the solution had varied in time function from one extracts concentration to another. Khaya senegalensis barks total extracts had reduced hepatic liberation of glucose. This effect had been comparable to the effect of insulin 2,5IU solution used like reference substance in this experimentation. The total extracts of Khaya senegalensis barks could actuate on enzymes implicated in the metabolism of intra hepatocytary glucose. Conclusion: This investigation had been coupled to phytochimic analyses that showed the presence of saponoïdes, anthracitic derivers and steroids in Khaya senegalensis barks.
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