Electrochemical sensors are gaining attention for the detection and quantification of pharmaceuticals in the environment. To that end, there is an interest in understanding the electrochemical characteristics of drugs. Herein, the multi-purpose drug auranofin is investigated for the first time in aqueous media. This compound offers therapeutic benefits in strains of cancer, parasites, bacteria and fungi, which have grown immune to many antibiotics. Auranofin detection was optimized at carbon black-modified electrodes. Voltammetry provides information about redox potentials, levels of detection and quantification, and pH dependence. Parameters identified in this study will be useful for auranofin sensing in environmental samples, and for studies related to drug resistance.
The electrochemical characterization and detection of antibiotic compounds are essential to understand and address the issues of drug-resistance in bacteria. In this work, we have characterized a varieties of antibiotic compounds such as Ciprofloxacin, Tobramycin, and a novel hybrid of both Ciprofloxacin and Tobramycin (Cip-Tob) over modified and unmodified glassy carbon electrodes. The working electrodes were modified using various carbonaceous catalyst support such as Carbon Black and functionalized Carbon Nanotubes, etc. Various electrochemical measurements such as cyclic voltammetry and differential pulse voltammetry were performed and they revealed the ultra-sensitivity of the modified electrodes towards the detection of antibiotics.
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