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When users choose a product, they consider the emotional experience triggered by the product form. In view of the fact that traditional kansei engineering can not effectively reflect the complex and changeable psychological factors of users, and it has not explored the complex relationship between customer satisfaction and perceptual demand characteristics through quantitative analysis. To address this problem, some uncertainty techniques including rough sets and fuzzy sets are applied to capture more accurate emotion knowledge. Therefore, this research proposes an integrated evaluation gird method (EGM), rough set theory (RST), continuous fuzzy kano model (CFKM), fuzzy weighted association rule mining method to extract the significant relationship between user needs and product morphological features. The EGM is applied to analyze the attractive factor of morphological characteristics of the product, and then the demand items with the highest satisfaction are analyzed through CFKM. The semantic difference method is combined to construct a decision table, and through attribute reduction and importance calculation to obtain the weight of the core product design items. In order to explore the non-linear relationship between design elements and kansei images, the fuzzy weighted association rule mining method was applied to obtain the set of frequent fuzzy weighted association rules based on evidence theory’s reliability indices of minimum support and confidence so as to realize user demand-driven product design. Taking the design of electric bicycle as an example, the experiment results show that the proposed method can help companies or designers develop products to generate good solutions for customer need.

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Toxicological studies have revealed the adverse impacts of organophosphate flame retardants (OPFRs) on the respiratory system, while there is a lack of epidemiological evidence, and information for risk assessment remains insufficient. Herein, we investigated the associations of urinary metabolites of OPFRs with the lung function in 987 adults participating in the U.S. National Health and Nutrition Examination Survey 2011–2012. The elevation of three primary metabolites of chlorinated OPFRs [bis(1,3-dichloro-2-propyl) phosphate (BDCIPP), bis(2-chloroethyl) phosphate (BCEP), and bis(1-chloro-2-propyl) phosphate (BCIPP)] was related to pulmonary dysfunction in a sample-weighted regression model. Each one-unit increase in the log-transformed levels of BDCIPP and BCEP was related to 91.52 and 79.34 mL reductions in the forced vital capacity (FVC). Each one-unit elevation in BCIPP was correlated with 130.86, 153.56, 302.26, and 148.24 mL reductions in forced expiratory volume 1st second (FEV1), FVC, peak expiratory flow rate (PEF), and forced expiratory flow at 25-75% of FVC (FEF25–75%), respectively. Then, an adverse outcome pathway (AOP) framework was constructed using the Comparative Toxicogenomics Database, the Toxicity Forecaster, and the GeneCards database. Based on the weight of the evidence, BDCIPP, BCEP, BCIPP, and their parent compounds (TDCIPP, TCEP, and TCIPP) may affect the IL-6/Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway, induce airway remodeling, and impair the lung function. Additionally, tobacco smoke exposure may modify the effects of BDCIPP on the lung function (P int < 0.05) and affect the IL-6-mediated AOP. These results suggested that chlorinated OPFRs were associated with pulmonary dysfunction via the IL-6/JAK/STAT pathway.

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