Background: EpCAM is highly expressed on tumor and tumor-initiating cells. Results: EpCAM induces reprogramming factor and EMT gene expression, which regulates tumor self-renewal and tumorigenesis. Conclusion: EpCAM-mediated self-renewal and initiation of tumor cells are regulated by inducing reprogramming factors expressions. Significance: Our data reveal the mechanism underlying EpCAM-mediated tumor initiation and tumorigenesis of tumorinitiating cells in colon cancer.
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